Results 81 to 90 of about 173,448 (288)

How Sediment Transport Sways Wetland Stability

Eos, 2016
Scientists examine the role of variables like tides and suspended sediment concentration to improve methods of evaluating coastal wetlands and how they may respond to future sea level rise.
openaire   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

An evaluation of metal removal during wastewater treatment: The potential to achieve more stringent final effluent standards [PDF]

, 2011
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 Taylor & Francis.Metals are of particular importance in relation to water quality, and concern regarding the impact of these ...
Arundel J., Barnes D., Barth E. F., Birkett J. W., Brown H. G., Chen K. Y., Cheng M. H., D. Ziolko, Davis J. A., Eckenfelder W. W., Esmond S. E., Fatoki O. S., Gray N. F., Groombridge B., Hawksworth D. L., Henson M. C., J. N. Lester, Klein L. A., Koch C. M., Koch M., Landner L., Landner L., Lawson P. S., Le Quesne T., Lester J. N., Lester J. N., Lester J. N., Lester J. N., Lester J. N., Liu Y., M. D. Scrimshaw, Malaney G. W., Mowat A., Neufeld R. D., Neufeld R. D., O. V. Martin, Raposo J. C., Reid W., Roberts P., Rossin A. C., Rudd T., Rule K. L., Spath R., Stander L., Stasinakis A. S., Stonebrook H., Stover R. C., Takiguchi M., Tomlinson T. G., Verma M. M., Yeoman S.   +50 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Storage Stability of Bimodal Emulsions vs. Monomodal Emulsions

Applied Sciences, 2017
Storage stability is a very important parameter that has to be considered in the formulation of asphalt emulsions. When monomodal emulsions are formulated, Stokes’ law is fulfilled, therefore the higher the viscosity the less sedimentation, or the lower ...
Nuria Querol, Camila Barreneche, Luisa F. Cabeza   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A Methodology to Evaluate the Real-Time Stability of Submarine Slopes under Rapid Sedimentation

Journal of Marine Science and Engineering
Rapid sedimentation is widely recognized as a crucial factor in initiating the instability of submarine slopes. Once the slope fails, the subsequent landslide poses a significant threat to the safety of underwater infrastructures and potentially leads to
Zehao Wang, Defeng Zheng, Zhongde Gu, Xingsen Guo, Tingkai Nian   +4 more
doaj   +1 more source

Functional Properties of Casein Added with Catechin Extracted from Cocoa Husk

Jurnal Ilmu dan Teknologi Hasil Ternak, 2019
Casein is one of the major protein components in milk. Its functional properties allow casein to be preferred by the consumers. In addition, casein could be collected as bioactive compositions to be added to food. The purpose of this study was to observe
Premy Puspitawati Rahayu, Djalal Rosyidi, Purwadi Purwadi, Imam Thohari   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source