Results 91 to 100 of about 188,409 (303)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Antioxidant activity and properties of walnut brown seed coat extract [PDF]

, 2016
To date, there are few studies about the properties of walnut brown seed coat. The antioxidant activity and properties of walnut brown seed coat was considered in this study and the amounts of carotenoids, chlorophylla, chlorophyllb, vitamin E were ...
Asadi-Samani, M., Bahmani, M., Godarzi, S., Sadighara, P.   +3 more
core   +1 more source

Mechanism of endocarp-imposed constraints of germination of Lannea microcarpa seeds [PDF]

, 2008
Lannea microcarpa, a multipurpose tree species from the dry African savanna, sheds seeds that often display inhibition of germination. The underlying mechanism was investigated using seeds processed from fully matured fruits collected from natural stands
Golovina, E.A., Hoekstra, F.A., Neya, O.
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Isolation of nuclear proteins from flax (Linum usitatissimum L.) seed coats for gene expression regulation studies

BMC Research Notes, 2012
Background While seed biology is well characterized and numerous studies have focused on this subject over the past years, the regulation of seed coat development and metabolism is for the most part still non-elucidated.
Renouard Sullivan, Cyrielle Corbin, Lopez Tatiana, Lamblin Frédéric, Lainé Eric, Hano Christophe   +5 more
doaj   +1 more source

Ultrastructural studies of soybean seed-borne infection by Diaporthe phaseolorum var. sojae and screening of antagonistic potentiality by selected biocontrol agents in vitro [PDF]

, 2008
The association of Diaporthe phaseolorum var. sojae with soybean seed decay was examined by ultrastructural studies using light microscopy and scanning electron microscopy. The fungus was detected over the seed surface as whitish-grey mycelial growth and
Begum, Most Mahbuba, Meon, Sariah, Mior Ahmad, Zainal Abidin, Puteh, Adam, Rahman, Md. Aminur   +4 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A Legume Biofortification Quandary: Variability and genetic control of seed coat micronutrient accumulation in common beans

Frontiers in Plant Science, 2013
Common beans (Phaseolus vulgaris L.), like many legumes, are rich in iron, zinc and certain other microelements that are generally found to be in low concentrations in cereals, other seed crops, and root or tubers and therefore are good candidates for ...
Matthew W. Blair, Paulo eIzquierdo, Carolina eAstudillo, Michael A. Grusak   +3 more
doaj   +1 more source

Potent endogenous allelopathic compounds in Lepidium sativum seed exudate: effects on epidermal cell growth in Amaranthus caudatus seedlings [PDF]

, 2012
Many plants exude allelochemicals – compounds that affect the growth of neighbouring plants. This study reports further studies of the reported effect of cress (Lepidium sativum) seed(ling) exudates on seedling growth in Amaranthus caudatus and Lactuca ...
Fry, Stephen, Iqbal, Amjad
core   +2 more sources