Results 91 to 100 of about 5,970,847 (335)

Dividing the pie: A quantitative review on plant density responses.

Plant, Cell and Environment, 2020
Plant population density is an important variable in agronomy and forestry and offers an experimental way to better understand plant-plant competition.
J. Postma, V. L. Hecht, K. Hikosaka, E. Nord, T. Pons, Hendrik Poorter   +5 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Magnetic Helicity Generation from the Cosmic Axion Field [PDF]

, 2005
The coupling between a primordial magnetic field and the cosmic axion field generates a helical component of the magnetic field around the time in which the axion starts to oscillate.
C. Caprini, D. Biskamp, E. N. Parker, E. W. Kolb, G. G. Raffelt, I. S. Gradshteyn, J. P. Vallée, L. Campanelli, M. Giannotti, Ya. B. Zeldovich   +9 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Analysis of Multiangle Wheat Density Effects Based on Drill Single-Seed Seeding

Agriculture
Explaining the physiological and ecological effects of wheat population density can provide new research methods for field crop production. A three-year field trial under drill single-seed seeding was conducted, which used three different intra-row seed-seedling spacings to quantitatively analyze the density effect from three perspectives—population ...
Haikang Li, Tchalla Korohou, Zhenyu Liu, Jing Geng, Qishuo Ding   +4 more
openaire   +2 more sources

IMPACT OF RAPE SEED DENSITY ON PRODUCTION PROFITABILITY

Annals of the Polish Association of Agricultural and Agribusiness Economists, 2017
The aim of the study was to compare the profitability of winter oilseed rape with two sowing methods: (row sowing – seed density 60 seeds per 1 m2 and spot sowing – seed density 40 seeds per 1 m2). The yield of rape seed was varied and was at the point sowing – 4.43 t/ha and row sowing – 5.24 t/ha.
Marek Gugała, Anna Sikorska, Krystyna Zarzecka, Ewa Krasnodębska, Krzyszof Kapela   +4 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Optimizing gold nanoparticle seeding density on DNA origami

RSC Advances, 2015
Characterization of various experimental parameters leads to optimized conditions for depositing linear strings of gold nanoparticle seeds on DNA origami.
E. P. Gates, J. K. Jensen, J. N. Harb, A. T. Woolley   +3 more
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source