Results 101 to 110 of about 5,322,660 (343)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Optimizing gold nanoparticle seeding density on DNA origami

RSC Advances, 2015
Characterization of various experimental parameters leads to optimized conditions for depositing linear strings of gold nanoparticle seeds on DNA origami.
E. P. Gates, J. K. Jensen, J. N. Harb, A. T. Woolley   +3 more
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Variáveis morfogênicas e estruturais de sorgo forrageiro implantado com diferentes arranjos populacionais sob pastoreio contínuo

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO O objetivo do estudo foi avaliar os efeitos da utilização de diferentes arranjos populacionais na implantação de sorgo forrageiro nas características morfogênicas e estruturais do pasto.
L.S. Rodrigues, D.C. Alves Filho, I.L. Brondani, V.S. Silva, P.C. Paula, S.M. Adams, P.M. Martini, A.P.M. Martini   +7 more
doaj   +1 more source

An Investigation of Seed Treatments for the Control of Crow Damage to Newly-Sown Wheat [PDF]

, 2007
End of project reportSeed treatments for the control of crow damage to newly-sown winter and spring wheat were evaluated in field trials from 2004 to 2007. Treatments included six fungicides, three insecticides, a product marketed as a bird repellent and
Connery, J., Kennedy, T.F.
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Weed seed bank dynamics under various rotations and field production resources

پژوهشهای زراعی ایران, 2009
Weed seed bank dynamics in corn, sugar beet and wheat plots in rotation with wheat were studied under conventional and ecological management systems during 2 years. The experiment was laid out in a split- plot design in a randomized complete block, where
leyla alimoradi, alireza koochaki, mehdi nassiri mahalati, ahmad zare feyz abadi   +3 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Effect of different seed densities on biomass production and nutritive value of barley fodder quality grown in hydroponic systems

Agronomy Science
We conducted this study to investigate the impact of various seed ratios on the growth rate, performance, nutritive value, and digestibility of fodder grown in a hydroponic system. Seeds were applied at 1000 g for high seed density treatment (HSD: 4.761
Hıdır Gümüş, Edyta Kowalczuk-Vasilev   +1 more
doaj   +1 more source

Effect of Plant Density on Yield and Yield Seed Components of Rapeseed (Brassica napus) Cultivars [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2013
To study the effects of different plant density on seed yield and yield components of three spring rapeseed cultivars a factorial experiment based on a Randomized Complete Block Design with three replications and 9 treatments was carried out during 2011 ...
M. Matinfar, M. Matinfar, M. Mahjoor, A.H. Shirani Rad, R. Mahmodi   +4 more
doaj