Results 71 to 80 of about 191,044 (310)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Evolutionary plant breeding for low input systems [PDF]
, 2005 Heritable variation is at the heart of the process of evolution. However, variation is restricted in breeding for uniform crop populations using the pedigree line approach. Pedigree lines are successful in agriculture because synthetic inputs are used to
Phillips, Scott, Wolfe, Martin
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Association of Fusarium and Phomopsis with Peroba Rosa Seeds
Floresta e Ambiente, 2019 Peroba rosa (Aspidosperma polyneuron) is a native forest species endangered due to intense predatory exploitation. The objective of this study was to evaluate the association and fungi transmission in peroba rosa seeds from four regions of Paraná ...
Edson José Mazarotto +3 more
doaj +1 more source
New Axisymmetric Stationary Solutions of Five-dimensional Vacuum Einstein Equations with Asymptotic Flatness [PDF]
, 2006 New axisymmetric stationary solutions of the vacuum Einstein equations in five-dimensional asymptotically flat spacetimes are obtained by using solitonic solution-generating techniques. The new solutions are shown to be equivalent to the four-dimensional
H. Stephani +5 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain [PDF]
Frontiers in Neuroscience, 2018 Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid-beta plaques. The presence and spread of tau pathology through the brain is classified by Braak stages and thought to correlate with the progression of AD.
Sarah L. DeVos +12 more
openaire +4 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Distribution and incidence of viruses in Irish seed potato crops [PDF]
, 2015 peer-reviewedVirus diseases are of key importance in potato production and in particular for the production of disease-free potato seed. However, there is little known about the frequency and distribution of potato virus diseases in Ireland.
Bonner, D. +6 more
core +1 more source