Results 71 to 80 of about 191,731 (311)

Seed-competent tau monomer initiates pathology in a tauopathy mouse model

Journal of Biological Chemistry, 2022
Tau aggregation into ordered assemblies causes neurodegenerative tauopathies. We previously reported that tau monomer exists in either inert (Mi) or seed-competent (Ms) conformational ensembles and that Ms encodes strains, that is, unique, self-replicating, biologically active assemblies.
Hilda Mirbaha, Dailu Chen, Vishruth Mullapudi, Sandi Jo Terpack, Charles L. White, Lukasz A. Joachimiak, Marc I. Diamond   +6 more
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Pathotypic diversity of Hyaloperonospora brassicae collected from Brassica oleracea [PDF]

, 2012
Downy mildew caused by Hyaloperonospora brassicae is an economically destructive disease of brassica crops in many growing regions throughout the world.
AA Monteiro, AG Channon, António A. Monteiro, B Agnola, BD Jensen, BM Irish, C Monot, C Sherriff, CE Thomas, CH Dickinson, D Leckie, D Leckie, D Silué, EB Holub, Eric B. Holub, F Delmotte, H Tapsoba, IR Crute, JA Lucas, JC Correll, JG Vicente, JJ Natti, JM Norwood, Joana G. Vicente, JR Greenhalgh, M Göker, M Wang, MH Dickson, MR Armstrong, NA Moss, NA Moss, NA Moss, NI Nashaat, NI Nashaat, P Coelho, Paula S. Coelho, SH Hulbert, T MacGregor, TW Hott, TW Hott, W Shan   +40 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Seed pathology [PDF]

Nature, 1978
Clark T. Rogerson, Paul Neergaard
openaire   +2 more sources

Tratamentos osmóticos e térmicos para controle de fungos em sementes de grumixameira (Eugenia brasiliensis Lam.) e pitangueira (Eugenia uniflora L.)

Hoehnea
As sementes de grumixama (Eugenia brasiliensis Lam.) e pitanga (Eugenia uniflora L.) são intolerantes à dessecação e seu elevado teor de água favorece a proliferação de fungos que podem acelerar sua deterioração.
Cibelle Ferreira Françoso, Claudio José Barbedo   +1 more
doaj   +1 more source

Association of Fusarium and Phomopsis with Peroba Rosa Seeds

Floresta e Ambiente, 2019
Peroba rosa (Aspidosperma polyneuron) is a native forest species endangered due to intense predatory exploitation. The objective of this study was to evaluate the association and fungi transmission in peroba rosa seeds from four regions of Paraná ...
Edson José Mazarotto, Ida Chapaval Pimentel, Daniela Cleide Azevedo de Abreu, Alvaro Figueredo dos Santos   +3 more
doaj   +1 more source

Characterising resistance to Turnip mosaic virus (TuMV) in Turnip (Brassica rapa rapa) [PDF]

, 2008
A Brassica rapa rapa L. line has been identified with high resistance to seven isolates of Turnip mosaic virus (TuMV) (including UK 1, CHN 5, CZE 1, CDN 1, GBR 6, POL 1 and UK 4) representing the major pathotypes of the virus.
Haj Kassem, Amin A., Walsh, John A.
core  

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain [PDF]

Frontiers in Neuroscience, 2018
Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid-beta plaques. The presence and spread of tau pathology through the brain is classified by Braak stages and thought to correlate with the progression of AD.
Sarah L. DeVos, Bianca T. Corjuc, Derek H. Oakley, Derek H. Oakley, Chloe K. Nobuhara, Riley N. Bannon, Alison Chase, Caitlin Commins, Jose A. Gonzalez, Patrick M. Dooley, Matthew P. Frosch, Matthew P. Frosch, Bradley T. Hyman   +12 more
openaire   +4 more sources