Results 71 to 80 of about 1,093,092 (310)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Seed quality and storage performance in mungbean and peanut : a thesis presented in partial fulfilment of the requirement for the degree of Master of Agricultural Science in Seed Technology, at Massey University, Palmerston North, New Zealand [PDF]

open access: yes, 1996
Five seedlots of mungbean and three seedlots of peanut were assessed for seed quality using six standard laboratory tests ie. purity analysis, seed moisture content, germination, seed health, and two vigour tests (accelerated ageing, and conductivity ...
Supradith, Uraiwan
core  

The AP2/ERF Gene Family in Camphor Tree: Structure, Evolution, and Transcriptional Response to Epicoccum Infection

open access: yesPlants
The AP2/ERF transcription factor family plays pivotal roles in plant growth, stress responses, and defense mechanisms, yet its diversity in camphor trees remains underexplored.
Jiexi Hou   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Analytic observations of seminar scientific work according toward objectives [PDF]

open access: yes, 2005
Report is Deliverable 9 of 6th FP SSA project “Environmental friendly food production system: requirements for plant breeding and seed production” (ENVIRFOOD) and includes analytic observations of seminar scientific work according toward objectives ...
Belicka, Ina, Bleidere, Mara
core  

Seed yield and quality as influenced by growing conditions in hybrid seed production of bitter gourd (Momordica charantia L.) cv. Pusa Hybrid-1 [PDF]

open access: yes, 2016
The present investigation was carried out under insect proof net house (IPN) and open field condition (OFC) at Centre for Protected Cultivation Technology and Seed Testing Laboratory of Division of Seed Science &Technology, IARI, New Delhi in bitter ...
Jat, G. S.   +5 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

SEED QUALITY OF SELECTED VEGETABLE SPECIES ON THE POLISH MARKET

open access: yesNotulae Botanicae Horti Agrobotanici Cluj-Napoca, 2006
In the years 2001-2003 the seed quality of 108 samples of white head cabbage, garden carrot, red beet, onion, cucumber, tomato, radish, lettuce, common bean and garden pea were checked.
Tomasz W. BRALEWSKI, Roman HOLUBOWICZ
doaj   +1 more source

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