Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Effectiveness of botanical preparations for the control of rice weevil (Sitophilus oryzae) during rice seed storage and their impact on the rice seed viability : a thesis presented in partial fulfilment of the requirements for the degree of Master of Applied Science in Seed Technology at Massey University, Palmerston North, New Zealand [PDF]
Food security and the maintenance of seed quality from harvest to planting are key issues for peasant farmers. In Sierra Leone, up to 28% of rice seed can be damaged by rice weevil in the six months storage period.
Sartie, Alieu Mortuwah
core
The giant genome of lily provides insights into the hybridization of cultivated lilies
Lilies are economically important monocots known for their ornamental flowers, bulbs, and large genomes. The absence of their genomic information has impeded evolutionary studies and genome-based breeding efforts.
Yuwei Liang +24 more
doaj +1 more source
Effect of common bean (Phaseolus vulgaris L.) seed viability on drying dynamics
‘Tina’ and ‘Libra’ cultivar seeds of the common bean (Phaseolus vulgaris L.) beginning germination capacity of 98%, were subjected to artificial ageing. In the thermal chamber, they were twice treated for 72 hours at 45°C.
Ratajczak Krzysztof, Hołubowicz Roman
doaj +1 more source
Vigor test of (strong) normal intact Amburana cearensis (Allemão) A.C. Smith seedlings
: The aim of this study was to adapt the vigor test methodology of (strong) normal intact seedlings of Amburana cearensis and evaluate efficiency in physiological classification of seed lots.
Josenilda Aprígio Dantas de Medeiros +5 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Wheat and barley seed system in Syria: farmers' varietal perceptions, seed sources and seed management [PDF]
A total of 206 wheat and 200 barley farmers were interviewed in northeastern Syria to understand farmer perceptions and practice relating to modern varieties, seed sources and seed quality. Wheat farmers had better awareness and grew modern varieties (87%
Bishaw, Z. +2 more
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This document is SS-AGR-187, one of a series of the Agronomy Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Original publication date November 2002.
Elmo B. Whitty
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The relationship between seed coat color and seed quality in watermelon Crimson sweet
This work was carried out to determine the relationship between seed coat color and seed quality in Crimson sweet watermelon. Seed lots (1, 2, 3, and 4) were prepared taking into consideration seed coat colors in fresh seeds with naked eye.
K. Mavi
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source

