Results 91 to 100 of about 4,885,715 (249)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Securing access to seed: social relations and sorghum seed exchange in eastern Ethiopia [PDF]

open access: yes, 2008
Access to seed is crucial for farming, though few studies investigate household-level access in the informal ‘farmer seed systems’ which still supply most seed in poor countries.
McGuire, Shawn J., McGuire, S.
core   +1 more source

Adaptive Seedling Strategies in Seasonally Dry Tropical Forests: A Comparative Study of Six Tree Species

open access: yesPlants
This study examines seed germination strategies and seedling establishment in six tree species typical of seasonally dry tropical forests. We focused on how interspecific and intraspecific differences in seed size and germination speed influence biomass ...
Carlos Ivan Espinosa   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Soil vs. canopy seed storage and plant species coexistence in species-rich Australian shrublands [PDF]

open access: yes, 2007
The fire-prone shrublands of southwestern Australia are renowned for their high plant species diversity and prominence of canopy seed storage (serotiny).
Johnson, N.   +13 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Determination of pore size distribution in soybean seed coats by mercury porosimetry

open access: yes, 2014
In this work we applied mercury porosimetry for the investigation of soybean seed coats. By using this method it was possible to determine the pore size distribution and also the pore size dispersion that is present in seed coats. The results showed that
La Scala, N.   +2 more
core  

Single-Plant Grain Yield in Corn (Zea mays L.) Based on Emergence Date, Seed Size, Sowing Depth, and Plant to Plant Distance [PDF]

open access: yes, 2022
The lack of seedling emergence uniformity in corn (Zea mays L.) is concerning for producers in the Midwestern U.S. These producers believe that just a few hours delay in emergence can increase interplant competition and decrease single-plant yield, thus ...
Kimmelshue, Chad L.   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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