Results 51 to 60 of about 13,314 (255)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
TOMATO SEEDS VIGOR UNDER WATER OR SALT STRESS
Revista Brasileira de Engenharia de Biossistemas, 2014 The aim of this study was to evaluate the water and salt stress in the germination process of two tomatoes cultivars. The experiment consisted of 16 treatments in a completely randomized design in triple 2 x 2 x 4 factorial design, with two tomatoes cultivars (Santa Adélia and Kátia), two imbibition solutions (PEG6000 and NaCl) and four osmotic ...
Silva Júnior, Josué Ferreira +5 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Biochemical Aspects of Seed Vigor
HortScience, 1980 Abstract It is beyond the purpose of this presentation to review all the definitions for the term “vigor” as applied to seeds. So far, no one definition has been accepted, and perhaps it is not yet time to settle on one definition until we know more about the subject.
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Effects of Purple Seed Stain on Seed Quality and Composition in Soybean
Plants, 2020 Purple seed stain disease, caused by (Cercospora kukuchii), is a major concern in soybean (Glycine max (L.)) in Mississippi, USA, due to its effects on seed quality, reducing soybean seed grade and potential market price at elevators.
Richard E. Turner +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Genome-Wide Association Analysis of Seed Vigor-Related Traits in Wheat
AgronomySeed vigor is a crucial indicator comprehensively assessing the quality of seeds, reflecting the growth advantage and production potential of seeds, and has a significant effect on seeds’ stress resistance.
Qinxuan Wu +9 more
doaj +1 more source
Methylation status of ACCase promoter affects seed vigor-viability trait in Oryza sativa L. [PDF]
Tropical Plant Research, 2018 Rice (Oryza sativa L.) varieties exhibiting phenotypic features of high/low seed vigor-viability were used to explore genetic controls associated with a varietal difference in seed vigor and viability traits. Since germination rate i.e.
Subhabrata Ghosh, Swati Sen-Mandi
doaj +1 more source