Results 91 to 100 of about 750,754 (312)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Effect of Foliar Application of Growth Stimulants and Priming on Yield and Grain Oil Content of Flax (Linum usitatissimum L.) [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2017
To investigate the effect of foliar application of plants with growth stimulants and seed priming on yield and seed oil content of flax, a factorial experiment was conducted at the Saatlo Agricultural and Natural Resources Research Center of West ...
Mahmoud Pouryousef Miandoab, Farnaz Esmaeilzadeh   +1 more
doaj  

Production of sainfoin seed yield [PDF]

, 2013
This study is summing up basic technological operations significant for successful sainfoin seed production. It gives summary of: optimal swaths per each production year, meteorological condition influences during production period; optimal sowing and seed density; and recommendation for optimal seed crop fertilization.
Vučković, Savo, Simić, Aleksandar, Prodanović, Slaven, Stanisavljević, Rade, Vasiljev, Boris, Čolić, Vladislava   +5 more
openaire  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Wheat and barley seed system in Syria: farmers' varietal perceptions, seed sources and seed management [PDF]

A total of 206 wheat and 200 barley farmers were interviewed in northeastern Syria to understand farmer perceptions and practice relating to modern varieties, seed sources and seed quality. Wheat farmers had better awareness and grew modern varieties (87%
Bishaw, Z., Gastel, A.J.G., van, Struik, P.C.   +2 more
core   +1 more source

Genotype and environment interaction on yield and quality parameters of organically grown winter wheat – Triticum aestivum L. genotypes [PDF]

, 2005
The interaction of genotype and environment upon yield and quality parameters of eight winter wheat (Triticum aestivum L.) genotypes was studied under organic conditions in Austria over two growing periods, 2001/2002 and 2002/2003, respectively.
Dashbaljir, Ichinkhorloo, Hartl, W., Liebhard, P., Loeschenberger, F., Weinhappel, M.   +4 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Impacts of Mycorrhiza and Phsphorus Along with the Use of Salicylic Acid on Maize Seed Yield [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2016
The effects of biological and chemical fertilizers, along with the use of salicylic acid, on the agronomic characteristics of corn in a factorial experiment based on randomized complete block design with three replications were evaluated at the ...
Fedra Taheri Oshtrinani, Amin Fathi
doaj  

Effect of seed size on soil cover, yield, yield components and nitrogen uptake of two-row malting barley

Die Bodenkultur, 2019
Seed size can influence germination, growth and yield formation of crops. A two-year field experiment was conducted in eastern Austria in 2012 and 2013 with two cultivars (Paula and Tatum) and four seeds size (< 2.5, 2.5–2.75, 2.75–3.25 and > 3.25 mm) to
Neugschwandtner Reinhard W., Papst Silvia, Kemetter Johannes, Wagentristl Helmut, Sedlář Ondřej, Kaul Hans-Peter   +5 more
doaj   +1 more source