Results 91 to 100 of about 4,823,194 (295)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Effects of the second crop on maize yield and yield components in organic agriculture [PDF]

, 2008
The second crop use in organic agriculture is a known method of maintaining the soil tilth, soil protection against environmental deterioration, soil nutrients conservation and even the weed control.
Jug, I., Samota, D., Vrkljan, B., Stipesevic, B., Kolar, D., Birkás, Márta, Jug, D.   +6 more
core   +1 more source

Producers' Use of Crop Borders for Management of Potato Virus Y (PVY) in Seed Potatoes [PDF]

Potato virus Y (PVY) is a very serious problem throughout most major seed potato producing states. Seed potato producers in Minnesota and North Dakota were surveyed in early 2005 to assess their perception of the profitability and risks associated with ...
Ragsdale, David W., Badibanga, Thaddee Mutumba, Olson, Kent D., Radcliffe, Edward B.   +3 more
core  

Analysis of Seed Potato Systems in Ethiopia [PDF]

, 2010
This study aimed to analyze the seed potato systems in Ethiopia, identify constraints and prioritize improvement options, combining desk research, rapid appraisal and formal surveys, expert elicitation, field observations and local knowledge. In Ethiopia,
Agajie Tesfaye, Hirpa, A., Oude Lansink, A.G.J.M., Willemien J. M. Lommen, Struik, P.C., Alfons Oude Lansink, Paul C. Struik, Miranda P. M. Meuwissen, Meuwissen, M.P.M., Tsegaye, A., Admasu Tsegaye, Lommen, W.J.M., Tesfaye, A., Adane Hirpa   +13 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Seed-setting traits of spike and yield components in two wheat cultivars, ‘Wennong6’ and ‘Jimai20’, grown under four different plant densities.

, 2016
Seed-setting traits of spike and yield components in two wheat cultivars, ‘Wennong6’ and ‘Jimai20’, grown under four different plant densities.
Min Jin (333526), Yong Li (15029), Zhenlin Wang (675456), Yingli Ni (675452), Mengjing Zheng (2802730), Yanping Yin (675457), Zhengyong Cui (675455), Dongqing Yang (675454), Jin Chen (130241)   +8 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Seed spacing variability reduces common bean yield

Pesquisa Agropecuária Tropical, 2019
An uneven seed spacing in the sowing row increases the plants intraspecific competition for environmental resources, potentially lowering grain yields.
Mateus Bortoluzi Bisognin, Osmar Henrique de Castro Pias, André Luis Vian, Claudir José Basso, Antônio Luis Santi   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source