Results 81 to 90 of about 87,070 (260)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Breeding for components of earliness and seed yield in sesame

Plant Gene and Trait, 2016
Sesame is an important oil crop not only in India but worldwide. Understanding of nature of inheritance of sesame plant characteristics is essential for planning of effective breeding strategies. Eight diverse genotypes of sesame were employed in a half-diallel mating to study combining abilities and assess potentials for earliness and seed yield ...
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

YIELD AND YIELD COMPONENTS OF INVESTIGATED RAPESEED HYBRIDS AND CULTIVARS [PDF]

Poljoprivreda, 2016
To evaluate new winter rapeseed hybrids and cultivars, investigations were conducted at the experimental field of the Faculty of Agriculture, University of Zagreb, in the period 2009/10 - 2011/12. The trial involved 11 hybrids and 5 cultivars rapeseed of
Milan Pospišil , Marina Brčić, Ana Pospišil , Jasminka Butorac   +3 more
doaj  

Analysis of seed yield components in oilseed Brassicas [PDF]

, 2008
Gajene vrste iz porodice Brassicaceae imaju veliki ekonomski značaj. U istraživanja su uključene dve sorte ozime uljane repice i dve sorte jare uljane repice (Brassica napus L.), dve sorte stočnog kelja (Brassica oleracea var. viridis) i dve sorte bele slačice (Sinapis alba L. subsp. alba syn. Brassica hirta). Ogled je postavljen u jesenjem i prolećnom
Marjanović-Jeromela, Ana, Marinković, Radovan, Jankulovska, Mirjana, Mikić, Aleksandar, Stojaković, Željka   +4 more
openaire  

Genetic determinism of seed yield components in lucerne

, 2023
Seed production is a major component of the commercial development of a variety but breeding for seed yield is expensive. A set of 400 cultivated lucerne accessions were phenotyped for seed yield traits in two locations and genotyped with GBS markers. A large diversity was found among accessions but the heritability of the traits was moderate. QTL were
Julier, Bernadette, Lefebvre, Héloïse, Zivanov, Dalibor, Pégard, Marie   +3 more
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Determination of Yield Components of Trigonelline in Fenugreek (Trigonella foenum-graceum L.) Seed Based on Path Analysis and Regression

Journal of Medicinal Plants, 2014
Background: Trigonelline in fenugreek seed is a valuable medicinal metabolite in reducing blood cholesterol and blood. Object: Determine the most important components of seed yield, percent and yield of seed trigonelline in fenugreek under foliar ...
MR Labbafi, H Naghdi Badi, E Zand, A Qaderi, Gh Noormohammadi, Gh Noormohammadi, H Khalaj, A Mehrafarin   +7 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source