Results 61 to 70 of about 87,070 (260)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The impact of drip irrigation and phosphorus fertilizer on enhancing dimorphic seed production of Lespedeza potaninii in Northwest China

Agricultural Water Management
Water shortage and poor soil fertility are two main limiting factors for crop production in semiarid region. We evaluated the effect of five irrigation times (0, 2, 3, 4 and 5 times with 50 mm per time) and four phosphorus fertilizer rates (0, 60, 90 and
Lijun Chen, Jingze Liu, Fukang Guo, Song Jing, Boyu Chu, Yuncan Qu, Wen Li, Jiyu Zhang   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Determination of Seed and Oil Yield and Yield Components in Two Variety of Milk Thistle (Silybum marianum Gaetrn.) Based on Path Analysis and Regression

Journal of Medicinal Plants, 2012
Background: Silybum marianum Gatrn. (Family: Asteraceae) is an annual or biennial plant, native to the Mediterranean area, which has spread in North and South of Iran.
N Qavami, MR Labbafi, MR Dehghani-Meshkani, A Mehrafarin   +3 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effect of seed size on soil cover, yield, yield components and nitrogen uptake of two-row malting barley

Die Bodenkultur, 2019
Seed size can influence germination, growth and yield formation of crops. A two-year field experiment was conducted in eastern Austria in 2012 and 2013 with two cultivars (Paula and Tatum) and four seeds size (< 2.5, 2.5–2.75, 2.75–3.25 and > 3.25 mm) to
Neugschwandtner Reinhard W., Papst Silvia, Kemetter Johannes, Wagentristl Helmut, Sedlář Ondřej, Kaul Hans-Peter   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effect of Micronutrients Application and Spraying Yeast Extract on Yield and Yield Components of Wheat (Triticum aestivum L.)

Maǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ, 2019
A field experiment was conducted during winter season of 2018-2019, at Al-Qurna district (75 km north of Basrah city centre). The aim of experiment was studding the effect of five levels of micronutrients (MN), Fe, Zn, Mn, Cu, B, and Mo: 0, 2 and 4 kg ...
Miraje M.M. Al-Shamary, Kadhim H. Huthily   +1 more
doaj   +1 more source

Genetic variability of seed yield and seed yield components of autochthonous Lolium perenne L. populations

Genetika, 2013
The aim of this study was to examine genetic variability, heritability and correlation of seed yield components and seed yield of progenies of autochthonous populations and cultivars of perennial ryegrass, and that on the basis of these results distinguish genotypes that would be later used in the creation of new local cultivars of ...
Lakić, Željko, Sokolović, Dejan, Babić, Snežana, Vojin, Svetko, Ikanović, Jela, Veljović, Tatjana, Balalić, Igor   +6 more
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source