Results 71 to 80 of about 385,458 (304)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Genetic diversity evaluation of Cumin (Cumin cyminum L.) based on phenotypic characteristics. [PDF]

, 2011
In order to assess the genetic diversity of cumin and determine the traits effective on seed yield and cumin- aldehyde, forty nine cumin ecotypes which they are sub-populations belonged to nine populations from different provinces of Iran were evaluated ...
Abdul Kadir, Mihdzar, Bahraminejad, Alireza, Mohammadi Nejad, Ghasem   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

BIOMASS, YIELD AND LAND EQUIVALENT RATIO OF Helianthus annus L. IN SOLE CROP AND INTERCROPPED WITH Phaseolus vulgaris L. IN HIGH VALLEYS OF MEXICO [PDF]

, 2009
The aim of the present study was to estimate the production of biomass, yield, yield components and land equivalent ratio (LER) of sunflower 'Victoria' (Helianthus anuuss L.) in sole crop and intercropped with three cultivars of bean (Phaseolus vulgaris ...
FRANCO MORA, OMAR, FRANCO MORA, OMAR, Morales Rosales, Edgar Jesús, Morales Rosales, Edgar Jesús   +3 more
core  

2D association and integrative omics analysis in rice provides systems biology view in trait analysis. [PDF]

, 2018
The interactions among genes and between genes and environment contribute significantly to the phenotypic variation of complex traits and may be possible explanations for missing heritability.
Dai, Xinbin, Xu, Shizhong, Zhang, Wenchao, Zhao, Patrick X   +3 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The impact of drip irrigation and phosphorus fertilizer on enhancing dimorphic seed production of Lespedeza potaninii in Northwest China

Agricultural Water Management
Water shortage and poor soil fertility are two main limiting factors for crop production in semiarid region. We evaluated the effect of five irrigation times (0, 2, 3, 4 and 5 times with 50 mm per time) and four phosphorus fertilizer rates (0, 60, 90 and
Lijun Chen, Jingze Liu, Fukang Guo, Song Jing, Boyu Chu, Yuncan Qu, Wen Li, Jiyu Zhang   +7 more
doaj   +1 more source

Seed production studies in Ruzi grass (Brachiaria ruziziensis Germain and Everard) : a thesis presented in partial fulfilment of the requirement for the degree of Master of Agricultural Science in Seed Technology, at Massey University, Palmerston North, New Zealand [PDF]

, 1994
The effect of photoperiod on seed production in Ruzi grass (Brachiaria ruziziensis) was investigated in order to gain a better understanding of reproductive behaviour. The experiment was conducted in a controlled temperature glasshouse which provided day
Narongrit, Wongsuwan
core