Results 71 to 80 of about 87,070 (260)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Evaluation of Yield and Yield Components of Fennel (Foeniculum vulgare L.) With the Combined Application of Nitrogen, Phosphorus and Potassium Supplier Bacteria with Mycorrhizal Fungi in Low-Input Cropping System [PDF]

Journal of Agricultural Science and Sustainable Production, 2017
The effect of biofertilizers on the seed yield and yield components of fennel(Foeniculum vulgare L.), was studied as factorial experiment based on randomized complete block design with three replications and twelve treatments at the Research Farm of the ...
F zamani, R Amirnia, E Rezaei-chiyaneh, A rahimi   +3 more
doaj  

Effect of Spraying with some Growth Regulators and Microelements on Growth, Productivity and Oil Content of Sesame [PDF]

Journal of Plant Production
Two fields experiment were conducted at the Experimental Farm, Faculty of Agriculture, Menoufia University,Shebin El-Kom,Egypt during 2024and2025 summer seasons to examine spraying effect of four growth regulators namely control, naphthalene acetic acid ...
M. Abdelaal, Y. shahat
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Seed spacing variability reduces common bean yield

Pesquisa Agropecuária Tropical, 2019
An uneven seed spacing in the sowing row increases the plants intraspecific competition for environmental resources, potentially lowering grain yields.
Mateus Bortoluzi Bisognin, Osmar Henrique de Castro Pias, André Luis Vian, Claudir José Basso, Antônio Luis Santi   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Soybean yield and yield component distribution across the main axis in response to light enrichment and shading under different densities

Plant, Soil and Environment, 2010
A 2-year field experiment was conducted under light enrichment and shading conditions to examine the responses of seed yield and yield components distribution across main axis in soybean.
B. Liu, X.B. Liu, C. Wang, Y.S. Li, J. Jin, S.J. Herbert   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

YIELD AND YIELD COMPONENTS OF INVESTIGATED RAPESEED HYBRIDS AND CULTIVARS [PDF]

Poljoprivreda, 2014
To evaluate new winter rapeseed hybrids and cultivars, investigations were conducted at the experimental field of the Faculty of Agriculture, University of Zagreb, in the period 2009/10 - 2011/12. The trial involved 11 hybrids and 5 cultivars rapeseed of
Milan Pospišil, Marina Brčić, Ana Pospišil, Jasminka Butorac   +3 more
doaj