Results 51 to 60 of about 5,306 (256)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Parameterized Complexity of Segment Routing

IEEE INFOCOM 2025 - IEEE Conference on Computer Communications
Segment Routing is a recent network technology that helps optimizing network throughput by providing finer control over the routing paths. Instead of routing directly from a source to a target, packets are routed via intermediate waypoints. Between consecutive waypoints, the packets are routed according to traditional shortest path routing protocols ...
Cristina Bazgan, Morgan Chopin, André Nichterlein, Camille Richer   +3 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Analisa dan Perbandingan Kinerja Routing Protocol OSPF dan EIGRP dalam Simulasi GNS3

JISA (Jurnal Informatika dan Sains), 2019
Router is the network equipment for route the packet from one network segment to another in a bigscale network. Router can route packet because there is a routing table in router configuration.
Gede Andika Loka, Silvester Dian Handy Permana, Ketut Bayu Yogha Bintoro   +2 more
doaj   +1 more source

Adaptive personalized routing for vulnerable road users

IET Intelligent Transport Systems, 2022
This research presents an adaptive and personalized routing model that enables individuals with mobility impairments to save their route preferences to a mobility assistant platform.
Justice Darko, Larkin Folsom, Nigel Pugh, Hyoshin Park, Khadijeh Shirzad, Justin Owens, Andrew Miller   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Analysis on waypoint-segment routing and performance evaluation for LEO satellite networks

Dianxin kexue, 2023
A waypoint-segment routing (WSR) algorithm was proposed.Based on the predictable periodicity of the topological changes of satellite network, the location of satellite waypoints based on the link state of satellite nodes at the current moment was ...
Xin ZHAO, Guang ZHAO, Rui CHEN, Wennai WANG   +3 more
doaj   +2 more sources

Traffic scheduling method based on segment routing in software-defined networking

Tongxin xuebao, 2018
In order to address the multi-commodity flow problem for traffic scheduling in software-defined networking,a method based on segment routing was proposed.The proposed method pre-computed sets of candidate paths and attributes of these paths for all ...
Qian DONG, Jun LI, Yuxiang MA, Shujun HAN   +3 more
doaj  

Fast Reroute Mechanism for Satellite Networks Based on Segment Routing and Dual Timers Switching

Aerospace
Low-Earth-Orbit (LEO) satellite networks have the advantage of global internet coverage and low latency, and they have enjoyed great success in the past few years. In LEO satellite networks, laser-based inter-satellite links (ISLs) are widely employed to
Jinyan Du, Ran Zhang, Jiangbo Hu, Tian Xia, Jiang Liu   +4 more
doaj   +1 more source