Results 71 to 80 of about 2,848,933 (331)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Segment routing for effective recovery and multi-domain traffic engineering
, 2017 Segment routing is an emerging traffic engineering technique relying on Multi-protocol Label-Switched (MPLS) label stacking to steer traffic using the source-routing paradigm.
CUGINI, FILIPPO +9 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
RSU-Assisted Traffic-Aware Routing Based on Reinforcement Learning for Urban Vanets
IEEE Access, 2020 In urban vehicular ad hoc networks (VANETs), the high mobility of vehicles along street roads poses daunting challenges to routing protocols and has a great impact on network performance.
Jinqiao Wu, Min Fang, Haikun Li, Xiao Li
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Expect the unexpected: Sub-second optimization for segment routing [PDF]
, 2017 In this paper, we study how to perform traffic engineering at an extremely-small time scale with segment routing, addressing a critical need for modern wide area networks.
Gay, S, Hartert, R, Vissicchio, S
core +2 more sources
PASR: An Efficient Flow Forwarding Scheme Based on Segment Routing in Software-Defined Networking
IEEE Access, 2020 Software-Defined Networking provides flexible and efficient network management. However, the limited flow table space lead to many challenges for SDN networks on flexibility and scalability.
Ziyong Li, Yuxiang Hu
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Adaptive personalized routing for vulnerable road users
IET Intelligent Transport Systems, 2022 This research presents an adaptive and personalized routing model that enables individuals with mobility impairments to save their route preferences to a mobility assistant platform.
Justice Darko +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source