Results 81 to 90 of about 71,197 (235)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Analysis on waypoint-segment routing and performance evaluation for LEO satellite networks
Dianxin kexue, 2023 A waypoint-segment routing (WSR) algorithm was proposed.Based on the predictable periodicity of the topological changes of satellite network, the location of satellite waypoints based on the link state of satellite nodes at the current moment was ...
Xin ZHAO +3 more
doaj +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Exploiting SRv6 for Stateless and Per-Connection-Consistent Load Balancing
IEEE AccessThis paper proposes a new load-balancing method that supports Per-Connection Consistency (PCC) by leveraging ECMP with standardized routing protocols for operational simplicity.
Ryo Nakamura +4 more
doaj +1 more source
Optimization Strategy to Solve Transmission Interruption Caused by Satellite-Ground Link Switching
IEEE Access, 2020 Low earth orbit (LEO) satellite systems, an important part of the next generation of global communication systems, have the advantages of low transmission delay, low satellite cost and low launch cost.
Jirui Zhang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Upper and Lower Bounds for Competitive Online Routing on Delaunay Triangulations
, 2014 Consider a weighted graph G where vertices are points in the plane and edges are line segments. The weight of each edge is the Euclidean distance between its two endpoints.
Bonichon, Nicolas +4 more
core +1 more source
Laser Powder Bed Fusion of Alumina: Effects of Scanning Strategies on External and Internal Defects
Advanced Engineering Materials, EarlyView.This study investigates how scanning strategies affect pure alumina in laser powder bed fusion. Linear 45° scanning yields uniform surfaces but high porosity, while the island‐concentric strategy provides higher density with through‐holes favorable for infiltration. Findings highlight pathways toward optimizing defect‐free alumina parts.
Mohamed Abdelmoula +7 more
wiley +1 more source
Combined Coverage Area Reporting and Geographical Routing in Wireless Sensor-Actuator Networks for Cooperating with Unmanned Aerial Vehicles [PDF]
, 2009 In wireless sensor network (WSN) applications with multiple gateways, it is key to route location dependent subscriptions efficiently at two levels in the system.
Havinga, P.J.M. +2 more
core +2 more sources