Results 61 to 70 of about 71,197 (235)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Topology-Aware Bus Routing in Complex Networks of Very-Large-Scale Integration with Nonuniform Track Configurations and Obstacles

Complexity, 2021
As one of the most important routing problems in the complex network within a very-large-scale integration (VLSI) circuit, bus routing has become much more challenging when witnessing the advanced technology node enters the deep nanometer era because all
Ziran Zhu, Zhipeng Huang, Jianli Chen, Longkun Guo   +3 more
doaj   +1 more source

Concurrent Geometric Multicasting

, 2017
We present MCFR, a multicasting concurrent face routing algorithm that uses geometric routing to deliver a message from source to multiple targets. We describe the algorithm's operation, prove it correct, estimate its performance bounds and evaluate its ...
Bramas Quentin, Ducrocq Tony, Hwang F.K., Liu P. C., Ruben Gabriel K, Sanchez Juan A.   +5 more
core   +2 more sources

Robustly disjoint paths with segment routing [PDF]

Proceedings of the 14th International Conference on emerging Networking EXperiments and Technologies, 2018
Motivated by conversations with operators and by possibilities to unlock future Internet-based applications, we study how to enable Internet Service Providers (ISPs) to reliably offer connectivity through disjoint paths as an advanced, value-added service.
Aubry, François, Vissicchio, Stefano, Bonaventure, Olivier, Deville, Yves, the 14th International Conference on emerging Networking EXperiments and Technologies   +4 more
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RSU-Assisted Traffic-Aware Routing Based on Reinforcement Learning for Urban Vanets

IEEE Access, 2020
In urban vehicular ad hoc networks (VANETs), the high mobility of vehicles along street roads poses daunting challenges to routing protocols and has a great impact on network performance.
Jinqiao Wu, Min Fang, Haikun Li, Xiao Li
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

PASR: An Efficient Flow Forwarding Scheme Based on Segment Routing in Software-Defined Networking

IEEE Access, 2020
Software-Defined Networking provides flexible and efficient network management. However, the limited flow table space lead to many challenges for SDN networks on flexibility and scalability.
Ziyong Li, Yuxiang Hu
doaj   +1 more source