Results 71 to 80 of about 537,692 (296)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Deep Learning-Based Fully Automatic Segmentation of the Paranasal Sinuses in Chronic Rhinosinusitis Patients Using Computed Tomographic Images

IEEE Access
Chronic rhinosinusitis with nasal polyps (CRSwNP), as one of the most common chronic nasal inflammations, has been a major research focus in the field of rhinology due to its complex and varied pathophysiological features and suboptimal clinical ...
Yuhang Wang, Xiaolei Zhang, Weidong Du, Na Dai, Yi Lyv, Keying Wu, Yiyang Tian, Yuxin Jie, Yu Lin, Weipiao Kang   +9 more
doaj   +1 more source

Automatic Parametrization and Shadow Analysis of Roofs in Urban Areas from ALS Point Clouds with Solar Energy Purposes

ISPRS International Journal of Geo-Information, 2018
A basic feature of modern and smart cities is their energetic sustainability, using clean and renewable energies and, therefore, reducing the carbon emissions, especially in large cities. Solar energy is one of the most important renewable energy sources,
Mario Soilán, Belén Riveiro, Patricia Liñares, Marta Padín-Beltrán   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Uncertainty-Aware Semi-Supervised Method for Pectoral Muscle Segmentation

Bioengineering
The consistency regularization method is a widely used semi-supervised method that uses regularization terms constructed from unlabeled data to improve model performance.
Yutao Tang, Yongze Guo, Huayu Wang, Ting Song, Yao Lu   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments

Frontiers in Human Neuroscience
IntroductionIt is generally accepted that during body position changes from horizontal to vertical there is a short-lasting shift of a certain CSF volume from the cranium into the hydrostatically lower parts of the spinal space, which leads to transitory
I. Strbačko, M. Radoš, I. Jurjević, D. Orešković, M. Klarica, M. Klarica   +5 more
doaj   +1 more source