Results 141 to 150 of about 98,082 (308)

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Burnout and depression at work: the role of irrational beliefs, job demands and work-to-family spillover

, 2019
Izgorelost in depresivnost sodita med najpogostejši duševni motnji v delovnem okolju in se povezujeta s številnimi negativnimi posledicami, tako na osebni ravni kot tudi na ravni organizacije.
Sel, Kaja
core  

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Benefit of selinexor dose reduction on outcomes with selinexor, bortezomib and dexamethasone in patients with lenalidomide-refractory multiple myeloma: Subgroup analysis of the BOSTON trial. [PDF]

Br J Haematol
A subgroup analysis of efficacy, safety and QOL in patients who received selinexor in combination with bortezomib and dexamethasone (SVd) with and without selinexor dose reduction and who had lenalidomide‐refractory disease in the phase 3 BOSTON trial showed improvements in efficacy, quality of life (QOL) and safety outcomes with selinexor dose ...
Delimpasi S, Špička I, Butler JP, Stevens DA, Mesa MG, Bygrave C, Merlo GM, la Porte C, Dimopoulos MA.   +8 more
europepmc   +2 more sources

Compatibility of personal care thickening polymers in sulphate‐free surfactants

International Journal of Cosmetic Science, EarlyView.
Phase behaviour for alpha olefin sulfonate surfactant 10–15 wt% combined with 1 wt% sodium carboxy methyl cellulose, clearly indicating the sensitivity in miscibility when adding various levels of background salt. Abstract Objective Formulators today know that when traditional surfactants and polymers are replaced new problems occur. What was before a ‘
Tobias Halthur, Jonas Carlstedt, Marta Gubitosi, Debora W. Chang, Eric S. Johnson   +4 more
wiley   +1 more source

Modeling of solenoid actuator and calculation of magnetic force on armature

, 2017
V projektnem delu smo opisali delovanje linearnega elektromagnetnega aktuatorja, v nadaljevanju pa smo predstavili postopek računalniškega modeliranja dejanskega aktuatorja v programskem paketu Flux 3D.
Sel, Tadej
core  

CHARGE Syndrome: A Narrative Review and Update on Diagnosis, Assessment and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background CHARGE syndrome (CS) is a rare multisystemic genetic condition caused by a pathogenic variant in the DNA‐binding protein‐7 CHD7 gene. The condition affects the development of neural crest cells, which give rise to craniofacial structures, cranial nerves, ears, eyes and the heart, resulting in diverse and complex clinical features ...
Eleni M. van Gelder, Suzanna E. L. Temple, Niall Jefferson, David Brown, Kasee Stratton‐Gadke, Madelene Rich, Steve Rose, Kim Blake   +7 more
wiley   +1 more source

E-INSURANCE

, 2012
Zavarovalništvo je pomembna gospodarska panoga ter pomemben del finančnega sistema, katerega osnovna funkcija je zbiranje denarnih sredstev. Nedavni napredek v tehnologiji je korenito vplival na zavarovalništvo, saj je veliko zavarovalnic začelo splet ...
Sel, Tara
core  

Identification of Genetic Loci Conveying Resistance to Fusarium oxysporum f. sp. ciceris Race 0 in Chickpea

Plant Breeding, EarlyView.
ABSTRACT Chickpea (Cicer arietinum L.) is a legume that is widely consumed around the world due to its nutritional content. Fusarium oxysporum f. sp. ciceris is a serious, destructive pathogen that causes fusarium wilt disease and affects chickpea production.
Selda Kurt Ozyaramis, Talap Talapov, Canan Can, Muhammed Bahattin Tanyolac, Ahmed Rami al Saadi, Duygu Ates   +5 more
wiley   +1 more source

Volatile Organic Compounds Emitted by Fungi Have Substantial Effects on Growth and Disease Resistance in Arabidopsis thaliana

Plant, Cell &Environment, EarlyView.
ABSTRACT Volatile organic compounds (VOCs) emitted by certain fungi have previously been suggested to modulate plant development and their response to stresses. While some fungal species, such as Trichoderma harzianum, are known to produce VOCs, the production of VOCs in other phylogenetically divergent species, such as Mucor mucedo, was previously ...
Sara Yugueros, Asier Largo‐Gosens, Cristina Úbeda, Cristina Hernández‐Fernández, Alba Manga‐Robles, Diego Rebaque, Antonio Encina, Hugo Mélida   +7 more
wiley   +1 more source