Results 41 to 50 of about 10,542,246 (288)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Methods for structural characterisation of Quillaja saponins by electrospray ionisation ion trap multiple-stage mass spectrometry [PDF]

, 2008
This thesis describes methods for structural classification of Quillaja saponins based on high performance liquid chromatography hyphenated electrospray ionisation ion trap multiple-stage mass spectrometry, in combination with multivariate analysis ...
Bankefors, Johan
core   +1 more source

Sensing Technologies for Detection of Acetone in Human Breath for Diabetes Diagnosis and Monitoring

Diagnostics, 2018
The review describes the technologies used in the field of breath analysis to diagnose and monitor diabetes mellitus. Currently the diagnosis and monitoring of blood glucose and ketone bodies that are used in clinical studies involve the use of blood ...
Valentine Saasa, Thomas Malwela, Mervyn Beukes, Matlou Mokgotho, Chaun-Pu Liu, Bonex Mwakikunga   +5 more
doaj   +1 more source

Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients’ breath

Scientific Reports, 2022
Several studies highlighted a correlation between exhaled air volatile organic compounds (VOCs) and some pathological conditions, such as chronic kidney disease (CKD), chronic liver disease, etc.
Annalisa Romani, Giulia Marrone, Roberto Celotto, Margherita Campo, Chiara Vita, Carlo Chiaramonte, Andrea Carretta, Nicola Di Daniele, Annalisa Noce   +8 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Online monitoring of propofol concentrations in exhaled breath

Heliyon
Propofol, a widely used intravenous anesthetic agent, requires accurate monitoring to ensure therapeutic efficacy and prevent oversedation. Recent developments in modern analytical instrumentation have led to significant breakthroughs in on-line analysis
Xiaoxiao Li, Pan Chang, Wensheng Zhang
doaj   +1 more source

Application of Fecal Volatile Organic Compound Analysis in Clinical Practice: Current State and Future Perspectives

Chemosensors, 2018
Increasing interest is noticed in the potential of volatile organic compound (VOC) analysis as non-invasive diagnostic biomarker in clinical medical practice.
Sofia el Manouni el Hassani, Daniel J. C. Berkhout, Sofie Bosch, Marc A. Benninga, Nanne K. H. de Boer, Tim G. J. de Meij   +5 more
doaj   +1 more source

An Ion Mobility-Mass Spectrometry Imaging Workflow [PDF]

, 2020
Mass spectrometry imaging (MSI) is a powerful technique for the label-free spatially-resolved analysis of biological tissues. Coupling ion mobility (IM) separation with MSI allows separation of isobars in the mobility dimension and increases confidence ...
Steve, Creger, Ruwan T., Kurulugama, John, Fjeldsted, Daniela Mesa, Sanchez, Veerupaksh, Singla, Julia, Laskin   +5 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers

EBioMedicine, 2022
Summary: Background: Current data suggest that dietary fibre (DF) interaction with the gut microbiota largely contributes to their physiological effects. The bacterial fermentation of DF leads to the production of metabolites, most of them are volatile.
Audrey M. Neyrinck, Julie Rodriguez, Zhengxiao Zhang, Julie-Anne Nazare, Laure B. Bindels, Patrice D. Cani, Véronique Maquet, Martine Laville, Stephan C. Bischoff, Jens Walter, Nathalie M. Delzenne   +10 more
doaj   +1 more source