Results 1 to 10 of about 966,959 (266)

TLR9/NF-kB Pathway Regulates Brucella CpG DNA-mediated Cytokine Response in Human Peripheral Blood Mononuclear Cells [PDF]

Iranian Journal of Immunology, 2021
Background: It was reported that targeting the Toll-like receptor9(TLR9) signaling pathway can be a promising therapeuticstrategy forinterventions in various inflammatory and infectiousdiseases.
Yunzhi Peng, Wenhui Bai, Zhanli Wang, Hui Yu   +3 more
doaj   +1 more source

Identification of two novel type II topoisomerase mutations in Enterococcus spp. isolated from a hospital in China [PDF]

Archives of Biological Sciences, 2021
Type II topoisomerases, including DNA gyrase (GyrA) and topoisomerase IV (ParC), contribute to fluoroquinolone resistance in Enterococcus spp. This study investigated the mutational status of the quinolone resistance-determining regions (QRDRs) of GyrA ...
Su Rina, Peng Yunzhi, Wang Zhanli, Yu Hui, Wu Qi   +4 more
doaj   +1 more source

Comparative analysis of relative gene expression data reveals novel microRNAs in the artery of rats with renovascular hypertension [PDF]

Archives of Biological Sciences, 2020
Hypertension is associated with impaired vascular endothelial function. However, the regulatory mechanisms of vascular dysfunction in rats with renovascular hypertension (RVH) remain poorly understood.
Yu Hui, Hu Hai, Wang Zhanli
doaj   +1 more source

In silico analysis of prognostic and diagnostic significance of target genes from prostate cancer cell lines derived exomicroRNAs

Cancer Cell International, 2023
Background Cancer-secreted exovesicles are important for cell-to-cell communication by altering cancer-related signalling pathways. Exovesicles-derived miRNAs (exomiRNAs)-target genes can be useful for diagnostic and prognostic purposes. Methods ExomiRNA
Antonio Altuna-Coy, Xavier Ruiz-Plazas, Verónica Arreaza-Gil, José Segarra-Tomás, Matilde R. Chacón   +4 more
doaj   +1 more source

Exosomes Derived From Hypertrophic Cardiomyocytes Induce Inflammation in Macrophages via miR-155 Mediated MAPK Pathway

Frontiers in Immunology, 2021
The inflammatory immune microenvironment plays an important role in the development of cardiac hypertrophy. Exosomes have emerged as the potent modulators of inflammatory responses.
Hui Yu, Hui Yu, Lei Qin, Yunzhi Peng, Wenhui Bai, Zhanli Wang   +5 more
doaj   +1 more source

The lipidomic profile of the tumoral periprostatic adipose tissue reveals alterations in tumor cell’s metabolic crosstalk

BMC Medicine, 2022
Background Periprostatic adipose tissue (PPAT) plays a role in prostate cancer (PCa) progression. PPAT lipidomic composition study may allow us to understand the tumor metabolic microenvironment and provide new stratification factors.
Antonio Altuna-Coy, Xavier Ruiz-Plazas, Silvia Sánchez-Martin, Helena Ascaso-Til, Manuel Prados-Saavedra, Marta Alves-Santiago, Xana Bernal-Escoté, José Segarra-Tomás, Matilde R. Chacón   +8 more
doaj   +1 more source

A serum metabolic biomarker panel for early rheumatoid arthritis

Frontiers in Immunology, 2023
ObjectiveThere is an urgent need for novel biomarkers to improve the early diagnosis of rheumatoid arthritis (ERA). Current serum biomarkers used in the management of ERA, including rheumatoid factor and anti-cyclic citrullinated peptide (ACPA), show ...
Samantha Rodríguez-Muguruza, Samantha Rodríguez-Muguruza, Antonio Altuna-Coy, Verónica Arreaza-Gil, Marina Mendieta-Homs, Sonia Castro-Oreiro, Maria José Poveda-Elices, Nuria del Castillo-Piñol, Ramon Fontova-Garrofé, Ramon Fontova-Garrofé, Matilde R. Chacón   +10 more
doaj   +1 more source

Longitudinal serological assessment of type VI collagen turnover is related to progression in a real-world cohort of idiopathic pulmonary fibrosis

BMC Pulmonary Medicine, 2021
Background Remodeling of the extracellular matrix (ECM) is a central mechanism in the progression of idiopathic pulmonary fibrosis (IPF), and remodeling of type VI collagen has been suggested to be associated with disease progression.
Henrik Jessen, Nils Hoyer, Thomas S. Prior, Peder Frederiksen, Sarah R. Rønnow, Morten A. Karsdal, Diana J. Leeming, Elisabeth Bendstrup, Jannie M. B. Sand, Saher B. Shaker   +9 more
doaj   +1 more source

Metabolic Signatures of the Exposome—Quantifying the Impact of Exposure to Environmental Chemicals on Human Health

Metabolites, 2020
Human health and well-being are intricately linked to environmental quality. Environmental exposures can have lifelong consequences. In particular, exposures during the vulnerable fetal or early development period can affect structure, physiology and ...
Matej Orešič, Aidan McGlinchey, Craig E. Wheelock, Tuulia Hyötyläinen   +3 more
doaj   +1 more source

Assessing the Impacts of Preanalytical Field Sampling Challenges on the Reliability of Serum Aflatoxin B1-Lysine Measurements by Use of LC-MS/MS

Toxins, 2022
Aflatoxin exposure is endemic in developing countries with warm, humid climates that promote toxigenic mold growth on crops and foodstuffs. Estimating human aflatoxin exposure is key to identifying and abating contamination sources.
Nicholas C. Zitomer, Michael E. Rybak, Maya R. Sternberg   +2 more
doaj   +1 more source