Results 31 to 40 of about 966,959 (266)

Serum type XVI collagen is associated with colorectal cancer and ulcerative colitis indicating a pathological role in gastrointestinal disorders

Cancer Medicine, 2018
Altered extracellular matrix (ECM) remodeling is an important part of the pathology of gastrointestinal (GI) disorders. In the intestine, type XVI collagen (col‐16) plays a role in pathogenesis by affecting ECM architecture and induce cell invasion ...
Christina Jensen, Signe H. Nielsen, Joachim H. Mortensen, Jens Kjeldsen, Lone G. Klinge, Aleksander Krag, Henrik Harling, Lars N. Jørgensen, Morten A. Karsdal, Nicholas Willumsen   +9 more
doaj   +1 more source

Tumstatin, a Matrikine Derived from Collagen Type IVα3, is Elevated in Serum from Patients with Non–Small Cell Lung Cancer

Translational Oncology, 2018
OBJECTIVES: Fibrosis and cancer are characterized by extracellular matrix (ECM) remodeling. The basement membrane is mainly composed by collagen type IV and laminin.
Signe Holm Nielsen, Nicholas Willumsen, Susanne Brix, Shu Sun, Tina Manon-Jensen, Morten Karsdal, Federica Genovese   +6 more
doaj   +1 more source

Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene

Journal of Translational Medicine
Background From the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic adipose tissue (PPAT).
Silvia Sánchez-Martin, Antonio Altuna-Coy, Verónica Arreaza-Gil, Xana Bernal-Escoté, Joan Francesc Garcia Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas, Matilde R. Chacón   +8 more
doaj   +1 more source

Biomarkers and Parkinson's disease [PDF]

Brain, 2004
Biomarkers are characteristics that can be measured as an indicator of a normal biological process, and they have special relevance in Parkinson's disease. Parkinson's disease is a chronic neurodegenerative disorder that is difficult to study, given the site of pathology and because the resultant clinical phenotype fluctuates over time.
A W, Michell, S J G, Lewis, T, Foltynie, R A, Barker   +3 more
openaire   +2 more sources

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Multi-omics analyses of Dracocephalum moldavica L. reveal two flavonoid glycosyltransferases in tilianin biosynthesis

BMC Genomics
Background To explore reference genome of Dracocephalum moldavica L. and provide a basis for the study of the mechanism of tilianin biosynthesis. Results We present telomere-to-telomere (T2T) genome assembly with the size of 255.61 Mb and a contig N50 ...
Qian Zhao, Xiaoxue Zhang, Wenfang Wang, Hui Yu, Zhanli Wang   +4 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Recent Applications of Electronic-Nose Technologies for the Noninvasive Early Diagnosis of Gastrointestinal Diseases

Proceedings, 2017
Conventional methods for diagnosing gastrointestinal (GI) diseases have involved analysis of headspace volatile organic compounds (VOCs) present in the breath, urine, or fecal samples of patients.
Alphus Dan Wilson
doaj   +1 more source

Enhanced Fuzzy Elephant Herding Optimization-Based OTSU Segmentation and Deep Learning for Alzheimer’s Disease Diagnosis

Mathematics, 2022
Several neurological illnesses and diseased sites have been studied, along with the anatomical framework of the brain, using structural MRI (sMRI). It is critical to diagnose Alzheimer’s disease (AD) patients in a timely manner to implement preventative ...
Afnan M. Alhassan, The Alzheimer’s Disease Neuroimaging Initiative, The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing   +2 more
doaj   +1 more source