Results 1 to 10 of about 1,069 (160)

Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro [PDF]

Journal of Experimental & Clinical Cancer Research, 2012
Background Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown.
Ribeiro Ricardo, Monteiro Cátia, Cunha Virgínia, Oliveira Maria, Freitas Mariana, Fraga Avelino, Príncipe Paulo, Lobato Carlos, Lobo Francisco, Morais António, Silva Vítor, Sanches-Magalhães José, Oliveira Jorge, Pina Francisco, Mota-Pinto Anabela, Lopes Carlos, Medeiros Rui   +16 more
doaj   +12 more sources

Periprostatic Adipose Tissue Microenvironment: Metabolic and Hormonal Pathways During Prostate Cancer Progression [PDF]

Frontiers in Endocrinology, 2022
The periprostatic adipose tissue (PPAT) is a site of invasion of prostate cancer (PCa) and is part of the microenvironment. It was shown that PPAT secretes factors and fatty acids (FAs) that alter the microenvironment of the PCa.
Paula Alejandra Sacca, Juan Carlos Calvo, Juan Carlos Calvo   +2 more
doaj   +7 more sources

Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity—a pilot study [PDF]

Clinical Epigenetics, 2018
Background Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome of PPAT in PCa patients.
Yan Cheng, Cátia Monteiro, Andreia Matos, Jiaying You, Avelino Fraga, Carina Pereira, Victoria Catalán, Amaia Rodríguez, Javier Gómez-Ambrosi, Gema Frühbeck, Ricardo Ribeiro, Pingzhao Hu   +11 more
doaj   +20 more sources

Periprostatic adipose tissue promotes prostate cancer resistance to docetaxel by paracrine IGF-1 upregulation of TUBB2B beta-tubulin isoform. [PDF]

Prostate, 2021
Growing evidence supports the pivotal role played by periprostatic adipose tissue (PPAT) in prostate cancer (PCa) microenvironment. We investigated whether PPAT can affect response to Docetaxel (DCTX) and the mechanisms associated. Conditioned medium was
Liotti A, La Civita E, Cennamo M, Crocetto F, Ferro M, Guadagno E, Insabato L, Imbimbo C, Palmieri A, Mirone V, Liguoro P, Formisano P, Beguinot F, Terracciano D.   +13 more
europepmc   +8 more sources

The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders [PDF]

Frontiers in Pharmacology, 2021
The lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are highly prevalent worldwide. Clinical and experimental data suggest that the incidence of LUTS-BPH is higher in patients with vascular-related disorders such as in
Gabriela Reolon Passos, Ana Carolina Ghezzi, Edson Antunes, Mariana Gonçalves de Oliveira, Fabiola Zakia Mónica   +4 more
doaj   +5 more sources

Preoperative Multiparametric MRI‐Based Tumour–Periprostatic Adipose Tissue Interface Characterisation for Extraprostatic Extension Prediction in Prostate Cancer [PDF]

Cancer Medicine
Objective To evaluate the independent predictive value of tumour–periprostatic adipose tissue (PPAT) interface features on preoperative multiparametric magnetic resonance imaging (mpMRI) for extraprostatic extension (EPE) in prostate cancer and to ...
Subo Zhang, Leiming Huo, Zhitao Zhu, Jinxin Wan, Lei Xu, Jiabao Xia, Yongjun Xu, Jingfang Liu, Yan Zhao   +8 more
doaj   +3 more sources

Network and Gene Set Enrichment Analysis of Adipokine Drivers of Prostate Cancer; Unravelling the Mechanistic Link Between Excess Adiposity and Prostate Cancer Risk [PDF]

Cancer Medicine
Background Adiposity‐Based Chronic Disease (ABCD), a novel model housing obesity, insulin resistance, and adipokine‐related inflammation, increases the risk of aggressive prostate cancer (PCa), posttreatment PCa recurrence, and PCa mortality.
Zachary Dovey, Elena Tomas Bort, Jeffrey I. Mechanick   +2 more
doaj   +3 more sources

Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine [PDF]

Frontiers in Pharmacology, 2023
Background: The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators that interfere in prostate function. In this study, we examined the effect of periprostatic adipose tissue supernatant obtained from obese mice
Gabriela Reolon Passos, Mariana G. de Oliveira, Ana Carolina Ghezzi, Glaucia C. Mello, Carlos Arturo Levi D’Ancona, Simone Aparecida Teixeira, Marcelo Nicolas Muscará, Carla Beatriz Grespan Bottoli, Lucilia Vilela de Melo, Eliezer de Oliveira, Edson Antunes, Fabiola Zakia Mónica   +11 more
doaj   +2 more sources

The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention [PDF]

BMC Medicine, 2012
Recent studies demonstrated that obesity is associated with prostate cancer aggressiveness and prognosis. However, the mechanisms underlying this relationship are poorly understood.
Lughezzani Giovanni
doaj   +2 more sources

MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy [PDF]

Adipocyte, 2023
In this study, we evaluated the association between the PPAT volume and the prognosis of PCa patients after LRP. We retrospectively analysed data of 189 PCa patients who underwent LRP in Beijing Chaoyang Hospital.
Tianyu Xiong, Fang Cao, Guangyi Zhu, Xiaobo Ye, Yun Cui, Nianzeng Xing, Huibo Zhang, Yinong Niu   +7 more
doaj   +2 more sources