Results 1 to 10 of about 1,895,537 (160)

Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro [PDF]

Journal of Experimental & Clinical Cancer Research, 2012
Background Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown.
Ribeiro Ricardo, Monteiro Cátia, Cunha Virgínia, Oliveira Maria, Freitas Mariana, Fraga Avelino, Príncipe Paulo, Lobato Carlos, Lobo Francisco, Morais António, Silva Vítor, Sanches-Magalhães José, Oliveira Jorge, Pina Francisco, Mota-Pinto Anabela, Lopes Carlos, Medeiros Rui   +16 more
doaj   +8 more sources

Unbound and Periprostatic Adipose Tissue Cefazolin Pharmacokinetics in Robotic-Assisted Radical Prostatectomy [PDF]

Antibiotics
Background/Objectives: This study aimed to describe the population pharmacokinetics of cefazolin (CFZ) using unbound serum and periprostatic adipose tissue concentrations and to optimize dosing regimens for patients undergoing robotic-assisted radical ...
Toshiaki Komatsu, Yuki Takahashi, Yoko Takayama, Yuto Akamada, Masaomi Ikeda, Hideyasu Tsumura, Daisuke Ishii, Kazumasa Matsumoto, Masatsugu Iwamura, Hirotsugu Okamoto, Hideaki Hanaki, Katsuya Otori   +11 more
doaj   +6 more sources

A modified U-Net convolutional neural network for segmenting periprostatic adipose tissue based on contour feature learning [PDF]

Heliyon
Objective: This study trains a U-shaped fully convolutional neural network (U-Net) model based on peripheral contour measures to achieve rapid, accurate, automated identification and segmentation of periprostatic adipose tissue (PPAT). Methods: Currently,
Gang Wang, Jinyue Hu, Yu Zhang, Zhaolin Xiao, Mengxing Huang, Zhanping He, Jing Chen, Zhiming Bai   +7 more
doaj   +5 more sources

The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders [PDF]

Frontiers in Pharmacology, 2021
The lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are highly prevalent worldwide. Clinical and experimental data suggest that the incidence of LUTS-BPH is higher in patients with vascular-related disorders such as in
Gabriela Reolon Passos, Ana Carolina Ghezzi, Edson Antunes, Mariana Gonçalves de Oliveira, Fabiola Zakia Mónica   +4 more
doaj   +5 more sources

Periprostatic Adipose Tissue Microenvironment: Metabolic and Hormonal Pathways During Prostate Cancer Progression [PDF]

Frontiers in Endocrinology, 2022
The periprostatic adipose tissue (PPAT) is a site of invasion of prostate cancer (PCa) and is part of the microenvironment. It was shown that PPAT secretes factors and fatty acids (FAs) that alter the microenvironment of the PCa.
Paula Alejandra Sacca, Juan Carlos Calvo, Juan Carlos Calvo   +2 more
doaj   +5 more sources

The lipidomic profile of the tumoral periprostatic adipose tissue reveals alterations in tumor cell’s metabolic crosstalk [PDF]

BMC Medicine, 2022
Background Periprostatic adipose tissue (PPAT) plays a role in prostate cancer (PCa) progression. PPAT lipidomic composition study may allow us to understand the tumor metabolic microenvironment and provide new stratification factors.
Antonio Altuna-Coy, Xavier Ruiz-Plazas, Silvia Sánchez-Martin, Helena Ascaso-Til, Manuel Prados-Saavedra, Marta Alves-Santiago, Xana Bernal-Escoté, José Segarra-Tomás, Matilde R. Chacón   +8 more
doaj   +4 more sources

Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine [PDF]

Frontiers in Pharmacology, 2023
Background: The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators that interfere in prostate function. In this study, we examined the effect of periprostatic adipose tissue supernatant obtained from obese mice
Gabriela Reolon Passos, Mariana G. de Oliveira, Ana Carolina Ghezzi, Glaucia C. Mello, Carlos Arturo Levi D’Ancona, Simone Aparecida Teixeira, Marcelo Nicolas Muscará, Carla Beatriz Grespan Bottoli, Lucilia Vilela de Melo, Eliezer de Oliveira, Edson Antunes, Fabiola Zakia Mónica   +11 more
doaj   +2 more sources

MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy [PDF]

Adipocyte, 2023
In this study, we evaluated the association between the PPAT volume and the prognosis of PCa patients after LRP. We retrospectively analysed data of 189 PCa patients who underwent LRP in Beijing Chaoyang Hospital.
Tianyu Xiong, Fang Cao, Guangyi Zhu, Xiaobo Ye, Yun Cui, Nianzeng Xing, Huibo Zhang, Yinong Niu   +7 more
doaj   +2 more sources

Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene [PDF]

Journal of Translational Medicine
Background From the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic adipose tissue (PPAT).
Silvia Sánchez-Martin, Antonio Altuna-Coy, Verónica Arreaza-Gil, Xana Bernal-Escoté, Joan Francesc Garcia Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas, Matilde R. Chacón   +8 more
doaj   +2 more sources

Multiparametric MRI-based radiomics model integrating tumor lesion and periprostatic adipose tissue for predicting bone metastasis in prostate cancer [PDF]

Frontiers in Oncology
PurposeTo develop and validate a multiparametric MRI (mpMRI)-based radiomics model incorporating features from both the tumor lesion and periprostatic adipose tissue (PPAT) for predicting synchronous bone metastasis (BM) in patients with newly diagnosed ...
Qian Zheng, Qian Zheng, Ruihong Chen, Ruihong Chen, Yuying Xie, Yuying Xie, Sha Cui, Wenjin Bian, Jianting Li, Jianting Li, Limei Guo, Limei Guo, Yujing Zhang, Yujing Zhang, Wenjia Zhang, Wenjia Zhang, Butian Zhang, Xiaoli Song, Jinliang Niu   +18 more
doaj   +2 more sources