Results 11 to 20 of about 1,069 (160)

LRP10, PGK1 and RPLP0: Best Reference Genes in Periprostatic Adipose Tissue under Obesity and Prostate Cancer Conditions. [PDF]

Int J Mol Sci, 2023
Obesity (OB) is a metabolic disorder characterized by adipose tissue dysfunction that has emerged as a health problem of epidemic proportions in recent decades. OB is associated with multiple comorbidities, including some types of cancers.
Pérez-Gómez JM, Porcel-Pastrana F, De La Luz-Borrero M, Montero-Hidalgo AJ, Gómez-Gómez E, Herrera-Martínez AD, Guzmán-Ruiz R, Malagón MM, Gahete MD, Luque RM.   +9 more
europepmc   +9 more sources

A modified U-Net convolutional neural network for segmenting periprostatic adipose tissue based on contour feature learning [PDF]

Heliyon
Objective: This study trains a U-shaped fully convolutional neural network (U-Net) model based on peripheral contour measures to achieve rapid, accurate, automated identification and segmentation of periprostatic adipose tissue (PPAT). Methods: Currently,
Gang Wang, Jinyue Hu, Yu Zhang, Zhaolin Xiao, Mengxing Huang, Zhanping He, Jing Chen, Zhiming Bai   +7 more
doaj   +6 more sources

Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue [PDF]

BMC Medicine, 2012
Background Periprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic organ towards this fat depot.
Ribeiro Ricardo, Monteiro Cátia, Catalán Victoria, Hu Pingzhao, Cunha Virgínia, Rodríguez Amaia, Gómez-Ambrosi Javier, Fraga Avelino, Príncipe Paulo, Lobato Carlos, Lobo Francisco, Morais António, Silva Vitor, Sanches-Magalhães José, Oliveira Jorge, Pina Francisco, Lopes Carlos, Medeiros Rui, Frühbeck Gema   +18 more
doaj   +6 more sources

The lipidomic profile of the tumoral periprostatic adipose tissue reveals alterations in tumor cell’s metabolic crosstalk [PDF]

BMC Medicine, 2022
Background Periprostatic adipose tissue (PPAT) plays a role in prostate cancer (PCa) progression. PPAT lipidomic composition study may allow us to understand the tumor metabolic microenvironment and provide new stratification factors.
Antonio Altuna-Coy, Xavier Ruiz-Plazas, Silvia Sánchez-Martin, Helena Ascaso-Til, Manuel Prados-Saavedra, Marta Alves-Santiago, Xana Bernal-Escoté, José Segarra-Tomás, Matilde R. Chacón   +8 more
doaj   +4 more sources

Human Periprostatic Adipose Tissue: Secretome from Patients With Prostate Cancer or Benign Prostate Hyperplasia. [PDF]

Cancer Genomics Proteomics, 2019
Periprostatic adipose tissue (PPAT) directs tumour behaviour. Microenvironment secretome provides information related to its biology. This study was performed to identify secreted proteins by PPAT, from both prostate cancer and benign prostate ...
Sacca PA, Mazza ON, Scorticati C, Vitagliano G, Casas G, Calvo JC.   +5 more
europepmc   +7 more sources

Periprostatic adipose tissue thromboinflammation triggers prostatic neoplasia in early metabolic impairment: Interruption by rivaroxaban [PDF]

Life Sciences, 2023
Aims: Prostate cancer is among the highest incidence malignancies in men with a prevalence rate increasing in parallel to the rising global trends in metabolic disorders.
Abou-Kheir, Wassim G., Al-Saidi, Aya, AlZaim, Ibrahim, Darwiche, Nadine D., El-Nikhely, Nefertiti A., El-Yazbi, Ahmed F., Mougharbil, Nahed   +6 more
core   +5 more sources

Periprostatic Adipose Tissue as a Contributor to Prostate Cancer Pathogenesis: A Narrative Review. [PDF]

Cancers (Basel)
Periprostatic adipose tissue (PPAT) contributes to the pathogenesis of prostate cancer. The purpose of this study was to review and summarize the literature on the role of PPAT in prostate cancer pathogenesis. Moreover, we evaluated the clinical implication of PPAT in patients with prostate cancer.
Drewa J, Lazar-Juszczak K, Adamowicz J, Juszczak K.   +3 more
europepmc   +5 more sources

Anatomic distribution of periprostatic adipose tissue [PDF]

Cancer, 2003
AbstractBACKGROUNDBecause the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively.METHODSThe authors analyzed the ...
Heng, Hong, Michael O, Koch, Richard S, Foster, Richard, Bihrle, Thomas A, Gardner, Joanne, Fyffe, Thomas M, Ulbright, John N, Eble, Liang, Cheng   +8 more
openaire   +4 more sources

Unbound and Periprostatic Adipose Tissue Cefazolin Pharmacokinetics in Robotic-Assisted Radical Prostatectomy [PDF]

Antibiotics
Background/Objectives: This study aimed to describe the population pharmacokinetics of cefazolin (CFZ) using unbound serum and periprostatic adipose tissue concentrations and to optimize dosing regimens for patients undergoing robotic-assisted radical ...
Toshiaki Komatsu, Yuki Takahashi, Yoko Takayama, Yuto Akamada, Masaomi Ikeda, Hideyasu Tsumura, Daisuke Ishii, Kazumasa Matsumoto, Masatsugu Iwamura, Hirotsugu Okamoto, Hideaki Hanaki, Katsuya Otori   +11 more
doaj   +2 more sources

Peri-Prostatic Adipocyte-Released TGFβ Enhances Prostate Cancer Cell Motility by Upregulation of Connective Tissue Growth Factor [PDF]

Biomedicines, 2021
Periprostatic adipose tissue (PPAT) has emerged as a key player in the prostate cancer (PCa) microenvironment. In this study, we evaluated the ability of PPAT to promote PCa cell migration, as well as the molecular mechanisms involved.
Evelina La Civita, Antonietta Liotti, Michele Cennamo, Felice Crocetto, Matteo Ferro, Pasquale Liguoro, Amelia Cimmino, Ciro Imbimbo, Francesco Beguinot, Pietro Formisano, Daniela Terracciano   +10 more
doaj   +3 more sources