Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue [PDF]
BMC Medicine, 2012 Background Periprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic organ towards this fat depot.
Ribeiro Ricardo +18 more
doaj +9 more sources
Periprostatic Adipose Tissue as a Contributor to Prostate Cancer Pathogenesis: A Narrative Review [PDF]
CancersPeriprostatic adipose tissue (PPAT) contributes to the pathogenesis of prostate cancer. The purpose of this study was to review and summarize the literature on the role of PPAT in prostate cancer pathogenesis. Moreover, we evaluated the clinical implication of PPAT in patients with prostate cancer.
Julia Drewa
exaly +5 more sources
Preoperative Multiparametric MRI‐Based Tumour–Periprostatic Adipose Tissue Interface Characterisation for Extraprostatic Extension Prediction in Prostate Cancer [PDF]
Cancer MedicineObjective To evaluate the independent predictive value of tumour–periprostatic adipose tissue (PPAT) interface features on preoperative multiparametric magnetic resonance imaging (mpMRI) for extraprostatic extension (EPE) in prostate cancer and to ...
Subo Zhang +8 more
doaj +3 more sources
Network and Gene Set Enrichment Analysis of Adipokine Drivers of Prostate Cancer; Unravelling the Mechanistic Link Between Excess Adiposity and Prostate Cancer Risk [PDF]
Cancer MedicineBackground Adiposity‐Based Chronic Disease (ABCD), a novel model housing obesity, insulin resistance, and adipokine‐related inflammation, increases the risk of aggressive prostate cancer (PCa), posttreatment PCa recurrence, and PCa mortality.
Zachary Dovey +2 more
doaj +3 more sources
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity—a pilot study [PDF]
Clinical Epigenetics, 2018 Background Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome of PPAT in PCa patients.
Yan Cheng +11 more
doaj +8 more sources
Adipoparacrinology: periprostatic adipose tissue as an example [PDF]
Adipobiology, 2011 The global epidemic of obesity (globesity) and related cardiometabolic and cancer diseases has focused attention on adipose tissue biology and the role played by adipose-secreted bioactive molecules (adipokines, neurotrophic factors, fatty acids, prostaglandins, steroid hormones, vitamin D3, NO, H 2 S) in the regulation of a wide array of physiological
Nikolai Evtimov +5 more
openaire +2 more sources
Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice [PDF]
Cancer Prevention Research, 2018 AbstractObesity is associated with an increased incidence of high-grade prostate cancer and poor prognosis for prostate cancer patients. Recently, we showed that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages, was ...
Miki, Miyazawa +7 more
core +4 more sources
Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue [PDF]
Cancers, 2022 The increased global prevalence of metabolic disorders including obesity, insulin resistance, metabolic syndrome and diabetes is mirrored by an increased incidence of prostate cancer (PCa). Ample evidence suggests that these metabolic disorders, being characterized by adipose tissue (AT) expansion and inflammation, not only present as risk factors for ...
Ibrahim Alzaim +2 more
exaly +6 more sources
Periprostatic Adipose Tissue Displays a Chronic Hypoxic State that Limits Its Expandability
The American Journal of Pathology, 2022 White adipose tissue accumulates at various sites throughout the body, some adipose tissue depots exist near organs whose function they influence in a paracrine manner. Prostate gland is surrounded by a poorly characterized adipose depot called periprostatic adipose tissue (PPAT), which plays emerging roles in prostate-related disorders.
Roumiguié, Mathieu +16 more
openaire +3 more sources
Obesogenic Dysregulation of Human Periprostatic Adipose Tissue Promotes the Viability of Prostate Cells and Reduces Their Sensitivity to Docetaxel and Cabazitaxel [PDF]
Medical SciencesBackground: Periprostatic adipose tissue (PPAT) has been shown to play a significant role in prostate cancer (PCa) development and progression. This relationship is further exacerbated by obesity, as PPAT-secreted factors increase PCa aggressiveness and ...
Mariana Feijó +9 more
doaj +2 more sources