Results 31 to 40 of about 1,069 (160)

Advancing prostate cancer research: an exploration of periprostatic adipose stem cells [PDF]

Journal of Translational Medicine
Prostate cancer (PCa) is the most prevalent cancer among men, highlighting the urgent need for innovative treatment strategies. The periprostatic adipose tissue (PPAT) plays a crucial role in the PCa tumor microenvironment, with direct crosstalk between ...
Paula Alejandra Sacca, Juan Carlos Calvo
doaj   +2 more sources

The importance of periprostatic fat tissue thickness measured by preoperative multiparametric magnetic resonance imaging in upstage prediction after robot-assisted radical prostatectomy [PDF]

Investigative and Clinical Urology
Purpose: We analyzed the surgical results of patients who were treated and followed up for prostate cancer in our clinic to predict the relationship between periprostatic adipose tissue and patients with and without pathologically upstaged disease ...
Emre Uzun, Muhammed Emin Polat, Kazim Ceviz, Erkan Olcucuoglu, Sedat Tastemur, Yusuf Kasap, Samet Senel, Ozkan Ozdemir   +7 more
doaj   +2 more sources

Extracellular Vesicles Released From Prostate Cancer Cells Confer Pro-Tumor Properties to Adipocytes by Stimulating Lipolysis. [PDF]

Biofactors
Extracellular vesicles (EVs) from prostate cancer (PCa) cells induce the release of fatty acids (FFAs) from adipocytes, which in turn sustain tumor cell proliferation and migration via Akt activation. ABSTRACT There is consistent evidence of an association between obesity and the risk of prostate cancer (PCa). A crosstalk between PCa and adipocytes has
Giannitti G, Kamińska K, Marchesi S, Garavaglia R, Preosto I, Grzesiak M, Fontana F.   +6 more
europepmc   +2 more sources

Preclinical evaluation of waste-derived pomegranate extract (PWE) as a potential preventing and therapeutic agent for benign prostatic hyperplasia [PDF]

Frontiers in Molecular Biosciences
IntroductionBenign prostatic hyperplasia (BPH) is a highly prevalent age-related condition, affecting nearly half of men over 60 and up to 80% over 80 years old. Chronic inflammation and oxidative stress are recognized contributors to BPH progression and
Valeria Consoli, Valeria Consoli, Agata Grazia D’Amico, Claudio Russo, Emanuele Foderà, Daniela Passarella, Antonio Pecorino, Velia D’Agata, Luca Vanella, Luca Vanella, Valeria Sorrenti, Valeria Sorrenti   +11 more
doaj   +2 more sources

Periprostatic adipose tissue MRI radiomics-derived features associated with clinically significant prostate cancer [PDF]

Journal of Endourology, 2023
Background: Altered systemic and cellular lipid metabolism plays a pivotal role in the pathogenesis of prostate cancer (PCa). In this study, we aimed to characterize T1-magnetic resonance imaging (MRI)-derived radiomic parameters of periprostatic adipose tissue (PPAT) associated with clinically significant PCa (Gleason score ≥7 [3 + 4]) in a cohort of ...
Lee, D. I., Sandberg, A., Shahait, M., Tong, Y., Torigian, D. A., Udupa, J. K., Usamentiaga Fernández, Rubén   +6 more
core   +4 more sources

Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue. [PDF]

Cancers (Basel), 2022
AlZaim I, Al-Saidi A, Hammoud SH, Darwiche N, Al-Dhaheri Y, Eid AH, El-Yazbi AF.   +6 more
europepmc   +2 more sources

Periprostatic Adipose Tissue: A New Perspective for Diagnosing and Treating Prostate Cancer. [PDF]

J Cancer
Prostate cancer (PCa) is the most common tumor of the male genitourinary system. It will eventually progress to fatal metastatic castration-resistant prostate cancer, for which treatment options are limited. Adipose tissues are distributed in various parts of the body.
Cao H, Wang Y, Zhang D, Liu B, Zhou H, Wang S.   +5 more
europepmc   +3 more sources

Castration promotes the browning of the prostate tumor microenvironment

Cell Communication and Signaling, 2023
Background Adipose tissue has gained attention due to its potential paracrine role. Periprostatic adipose tissue surrounds the prostate and the prostatic urethra, and it is an essential player in prostate cancer progression.
Alejandro Alvarez-Artime, Belen Garcia-Soler, Pedro Gonzalez-Menendez, Sheila Fernandez-Vega, Rafael Cernuda-Cernuda, David Hevia, Juan C. Mayo, Rosa M. Sainz   +7 more
doaj   +1 more source

Human Periprostatic Adipose Tissue: its Influence on Prostate Cancer Cells [PDF]

Cellular Physiology and Biochemistry, 2012
Adipose microenvironment is involved in signaling pathways that influence prostate cancer (PCa) progression. However, the role of human periprostatic adipose tissue (PPAT) from patients with benign prostatic hyperplasia (BPH) has not been studied and compared to that of PPAT from PCa patients.
Sacca, Paula Alejandra, Pistone Creydt, Virginia, Choi, H., Mazza, Osvaldo Néstor, Fletcher, Sabrina Johanna, Fernández Vallone, Valeria Beatriz, Scorticati, Camila, Chasseing, Norma Alejandra, Calvo, Juan Carlos   +8 more
openaire   +3 more sources

Role of adipocyte browning in prostate and breast tumor microenvironment

Tzu Chi Medical Journal, 2022
Prostate cancer (PC) and breast cancer (BC) are the most common cancers in men and women, respectively, in developed countries. The increased incidence of PC and BC largely reflects an increase in the prevalence of obesity and metabolic syndrome.
Hui-Chen Ku, Ching-Feng Cheng
doaj   +1 more source