Results 31 to 40 of about 1,895,537 (160)

LRP10, PGK1 And RPLP0: Best Reference Genes in Periprostatic Adipose Tissue Under Obesity and Prostate Cancer Conditions [PDF]

International Journal of Molecular Sciences, 2023
Antonio J Montero-Hidalgo, Maria M Malagon, Manuel D. Gahete   +2 more
exaly   +2 more sources

Advancing prostate cancer research: an exploration of periprostatic adipose stem cells [PDF]

Journal of Translational Medicine
Prostate cancer (PCa) is the most prevalent cancer among men, highlighting the urgent need for innovative treatment strategies. The periprostatic adipose tissue (PPAT) plays a crucial role in the PCa tumor microenvironment, with direct crosstalk between ...
Paula Alejandra Sacca, Juan Carlos Calvo
doaj   +2 more sources

Periprostatic Adipose Tissue Promotes Prostate Cancer Resistance to Docetaxel by Paracrine IGF-1 Upregulation of TUBB2B Beta-Tubulin Isoform [PDF]

Prostate, 2021
Pasquale Liguoro, Pietro Formisano, Ciro IMBIMBO   +2 more
exaly   +2 more sources

Abstract 1251: Pioglitazone inhibits periprostatic white adipose tissue inflammation in obese mice

Cancer Research, 2017
Abstract Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and poor prognosis for PC patients. Recently, we showed that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages ...
Miki Miyazawa, Kotha Subbaramaiah, Priya Bhardwaj, Xi Kathy Zhou, Hanhan Wang, Domenick J. Falcone, Dilip D. Giri, Andrew J. Dannenberg   +7 more
openaire   +2 more sources

Preclinical evaluation of waste-derived pomegranate extract (PWE) as a potential preventing and therapeutic agent for benign prostatic hyperplasia [PDF]

Frontiers in Molecular Biosciences
IntroductionBenign prostatic hyperplasia (BPH) is a highly prevalent age-related condition, affecting nearly half of men over 60 and up to 80% over 80 years old. Chronic inflammation and oxidative stress are recognized contributors to BPH progression and
Valeria Consoli, Valeria Consoli, Agata Grazia D’Amico, Claudio Russo, Emanuele Foderà, Daniela Passarella, Antonio Pecorino, Velia D’Agata, Luca Vanella, Luca Vanella, Valeria Sorrenti, Valeria Sorrenti   +11 more
doaj   +2 more sources

The DNA methylation landscape of prostate cancer is associated with the lipid composition of periprostatic adipose tissue

Scientific Reports
DNA methylation, a major epigenetic event associated with prostate cancer (PCa) progression, has been suggested to be influenced by the lipid microenvironment.
Dorian Espi-Bastien, Nathanael Fort, Cyrille Guimaraes, Arulraj Nadaradjane, Frank Bruyere, Christophe Vandier, Pierre-Francois Cartron, Gaelle Fromont   +7 more
doaj   +2 more sources

Periprostatic Adipose Tissue: A New Perspective for Diagnosing and Treating Prostate Cancer. [PDF]

J Cancer
Prostate cancer (PCa) is the most common tumor of the male genitourinary system. It will eventually progress to fatal metastatic castration-resistant prostate cancer, for which treatment options are limited. Adipose tissues are distributed in various parts of the body.
Cao H, Wang Y, Zhang D, Liu B, Zhou H, Wang S.   +5 more
europepmc   +3 more sources

Fibrosis of Periprostatic Adipose Tissue: A Potential Marker of Prostate Cancer Aggressiveness. [PDF]

Cancers (Basel)
Background: Periprostatic adipose tissue (PPAT) fibrosis is a histological feature potentially linked to prostate cancer (PCa) aggressiveness, though its role is not fully understood. This study investigates the correlation between PPAT fibrosis and PCa aggressiveness and develops a radiomics model based on PPAT MRI features for non-invasive prediction.
Jin Y, Hu J, Wang G, Zhang Y, Bai Z, Huang M, Chen J.   +6 more
europepmc   +3 more sources

Transformer-Based Deep Learning Integrating Multi-Regional MRI and Clinical Features for Predicting Biochemical Recurrence After Radical Prostatectomy: A Multicenter Study. [PDF]

Cancer Med
ABSTRACT Background Existing deep learning models for predicting biochemical recurrence (BCR) after radical prostatectomy often ignore the biological context beyond the tumor. This study aims to develop and validate a transformer‐based model combining multi‐regional magnetic resonance imaging (MRI) features and clinical data to improve BCR prediction ...
Zhou M, Lu K, Liu Y, Xie Z, Lin B, Yang Q, Chen R, Yu L, Zhao Y.   +8 more
europepmc   +2 more sources

Castration promotes the browning of the prostate tumor microenvironment

Cell Communication and Signaling, 2023
Background Adipose tissue has gained attention due to its potential paracrine role. Periprostatic adipose tissue surrounds the prostate and the prostatic urethra, and it is an essential player in prostate cancer progression.
Alejandro Alvarez-Artime, Belen Garcia-Soler, Pedro Gonzalez-Menendez, Sheila Fernandez-Vega, Rafael Cernuda-Cernuda, David Hevia, Juan C. Mayo, Rosa M. Sainz   +7 more
doaj   +1 more source