Results 21 to 30 of about 1,895,537 (160)

A novel composite index of PSA and periprostatic adipose tissue quantification for enhancing high-grade prostate cancer prediction [PDF]

BMC Urology
Background To explore the efficacy of combining MRI-derived quantitative data on Periprostatic adipose tissue (PPAT) with clinical biomarkers, including prostate-specific antigen (PSA), to enhance the high-grade (PCa) screening.
Jie Xiong, Yunfan Liu, Xiaofeng Qiao, Guangyong Ai, Jiangqin Ma, Xiaojing He   +5 more
doaj   +2 more sources

Periprostatic adipose tissue-derived adipokine profile in prostate cancer patients reveals two distinct molecular phenotypes linked to obesity-related comorbidities: multifaceted role of lipocalin-2 [PDF]

Cell Communication and Signaling
Background Prostate cancer (PCa) is a hormone-dependent tumor and one of the most prevalent cancers in men worldwide. PCa progression is influenced by its interaction with the surrounding tumor microenvironment, highlighting the role of periprostatic ...
Jesús M. Pérez-Gómez, Antonio Prats-Escribano, Ignacio Gil-Duque, Laura Arroyo-Millán, Hugo Huertas-Cabrera, Miguel A. Núñez-Santos, Daniel J. López-Ruiz, Fernando Mata-Ordoñez, Teresa González-Serrano, Ignacio Ortea, Francisco Porcel-Pastrana, Marina Álvarez-Benito, Mélanie Planque, Julia Carrasco-Valiente, Enrique Gómez-Gómez, Rocío Guzmán-Ruiz, Antonio C. Fuentes-Fayos, Sarah-Maria Fendt, Manuel D. Gahete, André Sarmento-Cabral, María del Mar Malagón, Raúl M. Luque   +21 more
doaj   +2 more sources

Periprostatic adipose tissue-derived extracellular vesicles modulate prostate cancer cell behaviour in vitro according to tumour grade [PDF]

Molecular Medicine
Background Periprostatic adipose tissue (PPAT) actively interacts with prostate cancer (PCa) cells, partly through the release of extracellular vesicles (EVs).
Verónica Arreaza-Gil, Gabriela A. Altamirano, Antonio Altuna-Coy, Alazne Moreno-Lanceta, Silvia Sánchez-Martin, Natalia Diaz-Valdivia, Jordi Alcaraz, Xana Bernal- Escoté, Joan Francesc Garcia-Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas, Matilde R. Chacón   +12 more
doaj   +2 more sources

Radiologic Assessment of Periprostatic Fat as an Indicator of Prostate Cancer Risk on Multiparametric MRI [PDF]

Bioengineering
Prostate cancer remains one of the most prevalent malignancies among men, and emerging evidence proposed a potential role for periprostatic adipose tissue (PPAT) in tumor progression.
Roxana Iacob, Emil Radu Iacob, Emil Robert Stoicescu, Diana Manolescu, Laura Andreea Ghenciu, Radu Căprariu, Amalia Constantinescu, Iulia Ciobanu, Răzvan Bardan, Alin Cumpănaș   +9 more
doaj   +2 more sources

Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone [PDF]

Adipocyte
Periprostatic adipose tissue (PPAT) is a potential factor closely associated with prostate cancer (PCa) development. This study aimed to introduce normalized PPAT thickness, a novel imaging biomarker, as a PCa predictor for patients within the diagnostic
Tianyu Xiong, Liting Shen, Yunpeng Fan, Zhanliang Liu, Song Jin, Haoyu Wu, Zhenghan Yang, Yinong Niu   +7 more
doaj   +2 more sources

Preoperative dual-ROI mpMRI radiomics integrating intratumoral and periprostatic adipose tissue features with clinical factors for predicting positive surgical margins after radical prostatectomy [PDF]

Cancer Imaging
Objective To develop and validate a preoperative mpMRI-based radiomics–clinical nomogram integrating dual-region radiomics features from intratumoral lesions and periprostatic adipose tissue (PPAT) with clinical factors for predicting positive surgical ...
De-Shi Hong, Xiao-Hui Wu, Chao-Xia Ruan, Dong-Shan Pan, Xu-Feng Huang, En-Ming Yang, Jun-Long Wang, Fei Wang, Kang Li, Jie-Bin Lin, Le-Le Yang, Shao-Hao Chen, Shi-Xian Wang   +12 more
doaj   +2 more sources

Dual-region deep learning model integrating prostate and peri-prostatic adipose tissue MRI features for bone metastasis prediction in prostate cancer [PDF]

Frontiers in Oncology
Rationale and objectivesBone metastasis (BM) is pivotal in prostate cancer (PCa) management. This study developed a multimodal model integrating MRI-derived deep features from the prostate gland (PG) and periprostatic adipose tissue (PPAT) with clinical ...
Peng Qin, Bohao Liu, Huabin Su, Ziqiao Wang, Zhengxu Lin, Weian Zhu, Chen Zou, Qian Cai, Jianjie Wu, Jiayu Zheng, Xiao Zhao, Xuan Wen, Yun Luo   +12 more
doaj   +2 more sources

Adipose Dysfunction Caused by Obesity and Radiation Therapy Rewires the Prostate Stroma Toward Tumor Progression [PDF]

Cells
Obesity is associated with chronic adipose dysfunction characterized by oxidative stress, inflammation, senescence, and fibrosis, which can promote tumor progression.
Simran Takkar, Louise Monga-Wells, Arpita Chatterjee, Subodh M. Lele, Rebecca E. Oberley-Deegan   +4 more
doaj   +2 more sources

Incidence of periprostatic white adipose tissue inflammation in men with prostate cancer.

Journal of Clinical Oncology, 2017
63 Background: Obesity, a common cause of chronic inflammation, is associated with an increased risk of high grade, lethal prostate cancer (PC) and poor outcomes. The existence or clinical importance of periprostatic white adipose tissue inflammation (WATi) in patients (pts) with PC has not been previously described.
Ayca Gucalp, Neil M. Iyengar, Xi K. Zhou, Dilip D. Giri, Domenick J. Falcone, Hanhan Wang, Samantha Williams, Margaret D. Krasne, Ibrahim Yaghnam, Brian Kunzel, Patrick G. Morris, Lee Jones, Michael N. Pollak, Vincent Paul Laudone, Howard I. Scher, Clifford A. Hudis, Peter T. Scardino, James Andrew Eastham, Andrew J. Dannenberg   +18 more
openaire   +2 more sources

MRI-measured periprostatic to subcutaneous adipose tissue thickness ratio as an independent risk factor in prostate cancer patients undergoing radical prostatectomy

Scientific Reports
The purpose of this study is to evaluate whether the periprostatic adipose tissue thickness (PPATT) is an independent prognostic factor for prostate cancer patients after laparoscopic radical prostatectomy (LRP).
Shanshan Jiang, Yi Li, Yusheng Guo, Bingxin Gong, Chengcheng Wei, Weiwei Liu, Chao Chen, Feng Pan, Jiyu Song, Qingliu He, Lian Yang, Guofeng Zhou   +11 more
doaj   +2 more sources