Results 51 to 60 of about 1,895,537 (160)

Use of parallel fluorescent confocal microscopy for detection of prostatic adenocarcinoma. [PDF]

BJU Int
Objective To provide a histological catalogue and defined criteria for the diagnosis of prostatic adenocarcinoma and its variants using the fluorescent confocal microscope (FCM) platform. Methods A total of 22 radical prostatectomy specimens were serially sectioned and scanned with the FCM.
Clare K, Haines K, Littlefield J, Mandel A, Sur H, Tillu N, Jodka H, Ajabshir D, Ahmad F, Arora C, Pasat-Karasik C, Fatterpekar M, Tewari A, Zhou M.   +13 more
europepmc   +2 more sources

The importance of periprostatic fat tissue thickness measured by preoperative multiparametric magnetic resonance imaging in upstage prediction after robot-assisted radical prostatectomy [PDF]

Investigative and Clinical Urology
Purpose: We analyzed the surgical results of patients who were treated and followed up for prostate cancer in our clinic to predict the relationship between periprostatic adipose tissue and patients with and without pathologically upstaged disease ...
Emre Uzun, Muhammed Emin Polat, Kazim Ceviz, Erkan Olcucuoglu, Sedat Tastemur, Yusuf Kasap, Samet Senel, Ozkan Ozdemir   +7 more
doaj   +1 more source

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

Nature Communications, 2016
Obesity is associated with an elevated risk of prostate cancer. Here, the authors show that periprostatic adipose tissue promotes the migration and local invasion of prostate cancer cells by secreting the chemokine, CCL7, and that this process is ...
Victor Laurent, Adrien Guérard, Catherine Mazerolles, Sophie Le Gonidec, Aurélie Toulet, Laurence Nieto, Falek Zaidi, Bilal Majed, David Garandeau, Youri Socrier, Muriel Golzio, Thomas Cadoudal, Karima Chaoui, Cedric Dray, Bernard Monsarrat, Odile Schiltz, Yuan Yuan Wang, Bettina Couderc, Philippe Valet, Bernard Malavaud, Catherine Muller   +20 more
doaj   +1 more source

Androgen deprivation therapy promotes an obesity-like microenvironment in periprostatic fat

Endocrine Connections, 2019
Prostate cancer is a leading cause of morbidity and cancer-related death worldwide. Androgen deprivation therapy (ADT) is the cornerstone of management for advanced disease.
Stefano Mangiola, Ryan Stuchbery, Patrick McCoy, Ken Chow, Natalie Kurganovs, Michael Kerger, Anthony Papenfuss, Christopher M Hovens, Niall M Corcoran   +8 more
doaj   +1 more source

Adipose Tissue as an Endocrine Organ [PDF]

, 2018
As one of the largest endocrine organs in the body, adipose tissue secrets a number of bioactive hormones, called adipokines. The expression and secretion of adipokines are tightly controlled and coordinated by physiological and pathophysiological ...
Feng, T, Hui, X
core   +1 more source

Peri-Prostatic Adipocyte-Released TGFβ Enhances Prostate Cancer Cell Motility by Upregulation of Connective Tissue Growth Factor

Biomedicines, 2021
Periprostatic adipose tissue (PPAT) has emerged as a key player in the prostate cancer (PCa) microenvironment. In this study, we evaluated the ability of PPAT to promote PCa cell migration, as well as the molecular mechanisms involved.
Evelina La Civita, Antonietta Liotti, Michele Cennamo, Felice Crocetto, Matteo Ferro, Pasquale Liguoro, Amelia Cimmino, Ciro Imbimbo, Francesco Beguinot, Pietro Formisano, Daniela Terracciano   +10 more
doaj   +1 more source

Periprostatic Adipose Tissue MRI Radiomics-Derived Features Associated with Clinically Significant Prostate Cancer

Journal of Endourology, 2023
Background: Altered systemic and cellular lipid metabolism plays a pivotal role in the pathogenesis of prostate cancer (PCa). In this study, we aimed to characterize T1-magnetic resonance imaging (MRI)-derived radiomic parameters of periprostatic adipose tissue (PPAT) associated with clinically significant PCa (Gleason score ≥7 [3 + 4]) in a cohort of ...
Mohammed Shahait, Ruben Usamentiaga, Yubing Tong, Alex Sandberg, David I. Lee, Jayaram K. Udupa, Drew A. Torigian   +6 more
openaire   +3 more sources

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]

, 2016
Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Handschin, Christoph, Mitsugu Shimobayashi, Svensson, Kristoffer, Shimobayashi, Mitsugu, Muñoz, Sergio, Hall, Michael N., Verena Albert, Michael N Hall, Fatima Bosch, Albert, Verena, Kristoffer Svensson, Sergio Muñoz, Christoph Handschin, Bosch i Tubert, Fàtima, Colombi, Marco, Marco Colombi, Bosch, Fatima, Veronica Jimenez, Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG), Muñoz-Martínez, S, Jimenez, Veronica, Jimenez V, Albert V, Muñoz S, Shimobayashi M, Hall MN, Svensson K, Colombi M, Bosch F, Handschin C   +29 more
core   +1 more source

Periprostatic Adipose Tissue Mapping as a Diagnostic Predictor of Prostate Carcinoma

Journal of Radiology and Clinical Imaging, 2019
Periprostatic adipose tissue is a new topic being investigated to determine its utility in detecting and scoring prostate cancer. In the past, most of the studies related to prostate cancer relied on body mass index (BMI) to measure adiposity but showed conflicting results.
Shrestha Sukriti, Zhao Xinxiang
openaire   +1 more source

Exploratory Analysis of Peri‐Prostatic Adipose Tissue Radiomics Features and Their Potential to Predict Prostate Cancer Diagnosis: Results From a UK Biobank Study

The Prostate, EarlyView.
ABSTRACT Introduction This paper reports the development and application of an artificial intelligence (AI)–led approach to large volume MRI data curation and image segmentation of periprostatic adipose tissue (PPAT) in prostate cancer (PCa)–free men from the UK Biobank. We report how PPAT was defined, radiomics features of PPAT extracted, and explored
Angela O'Neill, Ryan O'Keeffe, Sarah Winter, Jade Dorrian, Tom R. Gaunt, Vilmundur Guönason, Ruth C. Travis, Richard M. Martin, Emma H. Allott, Michelle Leech   +9 more
wiley   +1 more source