Skeletal muscle–adipose tissue–tumor axis : molecular mechanisms linking exercise training in prostate cancer [PDF]
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Increased ...
Abade, Eduardo +9 more
core +3 more sources
Phase II prospective randomized trial of weight loss prior to radical prostatectomy. [PDF]
BACKGROUND:Obesity is associated with poorly differentiated and advanced prostate cancer and increased mortality. In preclinical models, caloric restriction delays prostate cancer progression and prolongs survival.
Aronson, William J +11 more
core +1 more source
Periprostatic fat measured on computed tomography as a marker for prostate cancer aggressiveness [PDF]
OBJECTIVE: Several reports found that obesity was associated with prostate cancer (PC) aggressiveness among men treated with radical prostatectomy or radiotherapy.
Joep G. H. van Roermund +35 more
core +1 more source
Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells [PDF]
Obesity confers an increased risk of developing specific cancer forms. Although the mechanisms are unclear, increased fat cell secretion of specific proteins (adipokines) may promote/facilitate development of malignant tumors in obesity via cross-talk ...
AG Renehan +30 more
core +4 more sources
Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley +4 more sources
Is there a role for stem cell therapy in erectile dysfunction secondary to cavernous nerve injury? Network meta-analysis from animal studies and human trials [PDF]
Introduction: We carried out systematic review and network meta-analysis to investigate the role of stem cell therapy (SCT) in the management of erectile dysfunction (ED) secondary to cavernous nerve injury in rats and post-radical prostatectomy (RP) in ...
Madaan, S. +7 more
core +1 more source
Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
Obesity is associated with an elevated risk of prostate cancer. Here, the authors show that periprostatic adipose tissue promotes the migration and local invasion of prostate cancer cells by secreting the chemokine, CCL7, and that this process is ...
Victor Laurent +20 more
doaj +1 more source
Androgen deprivation therapy promotes an obesity-like microenvironment in periprostatic fat
Prostate cancer is a leading cause of morbidity and cancer-related death worldwide. Androgen deprivation therapy (ADT) is the cornerstone of management for advanced disease.
Stefano Mangiola +8 more
doaj +1 more source
Analysis of p53 expression and proliferative assessment using PCNA in localized prostate carcinoma [PDF]
The surgical specimens from 51 men submitted to radical prostatectomy for localized prostate cancer were examined by immunohistochemistry using proliferation cell nuclear antigen (PCNA) monoclonal antibody to evaluate the proliferative index (PI).
Camara-Lopes, Luiz H +3 more
core +1 more source
Periprostatic Adipose Tissue and Prostate Cancer Progression: New Insights into the Tumor Microenvironment [PDF]
The high prevalence of both obesity and prostate cancer highlights the importance of understanding the biological features of this relationship. It is estimated that obesity accounts for an increase of about 15% in the incidence of high-grade prostate cancers over the past 30 years.
Paul, Toren, Vasundara, Venkateswaran
openaire +2 more sources

