Results 51 to 60 of about 966,959 (266)

Predicting metabolic biomarkers of human inborn errors of metabolism

Molecular Systems Biology, 2009
Early diagnosis of inborn errors of metabolism is commonly performed through biofluid metabolomics, which detects specific metabolic biomarkers whose concentration is altered due to genomic mutations.
Tomer Shlomi, Moran N Cabili, Eytan Ruppin   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Therapeutic effects of Mongolian medical warm acupuncture on neuropathic pain via gut microbiota and inflammatory pathway regulation in a chronic constriction injury rat model [PDF]

Archives of Biological Sciences
The study was designed to determine whether Mongolian medical warm acupuncture (MMWA) can alleviate neuropathic pain through regulating gut microbiota and inflammation-related pathways in the chronic constriction injury (CCI) rat model.
Meng Husileng, Yu Hong, Gang Suhe, Bo Agula, Wang Zhanli   +4 more
doaj   +1 more source

Giant cell arteritis: incidence and phenotypic distribution in Western Norway 2013–2020

Frontiers in Medicine, 2023
ObjectivesThere is an increasing awareness of the spectrum of phenotypes in giant cell arteritis (GCA). However, there is sparse evidence concerning the phenotypic distribution which may be influenced by both genetic background and the environment.
H. K. Skaug, H. K. Skaug, H. K. Skaug, B. T. Fevang, B. T. Fevang, J. Assmus, A. P. Diamantopoulos, G. Myklebust, L. K. Brekke, L. K. Brekke   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Periprostatic adipose tissue-derived extracellular vesicles modulate prostate cancer cell behaviour in vitro according to tumour grade

Molecular Medicine
Background Periprostatic adipose tissue (PPAT) actively interacts with prostate cancer (PCa) cells, partly through the release of extracellular vesicles (EVs).
Verónica Arreaza-Gil, Gabriela A. Altamirano, Antonio Altuna-Coy, Alazne Moreno-Lanceta, Silvia Sánchez-Martin, Natalia Diaz-Valdivia, Jordi Alcaraz, Xana Bernal- Escoté, Joan Francesc Garcia-Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas, Matilde R. Chacón   +12 more
doaj   +1 more source

Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness

Journal of Translational Medicine, 2019
Background Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assessment of PCa aggressiveness ...
Xavier Ruiz-Plazas, Esther Rodríguez-Gallego, Marta Alves, Antonio Altuna-Coy, Javier Lozano-Bartolomé, Manel Portero-Otin, Joan Francesc García-Fontgivell, Salomé Martínez-González, José Segarra, Matilde R. Chacón   +9 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Biomarkers in Airway Diseases [PDF]

Canadian Respiratory Journal, 2013
The inherent limitations of spirometry and clinical history have prompted clinicians and scientists to search for surrogate markers of airway diseases. Although few biomarkers have been widely accepted into the clinical armamentarium, the authors explore three sources of biomarkers that have shown promise as indicators of disease severity and treatment
Janice M Leung, Don D Sin
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source