Results 41 to 50 of about 301,728 (217)

Monitoring casbene synthase in Jatropha curcas tissues using targeted proteomics

open access: yesPlant Methods, 2021
Background Casbene synthase (CS) is responsible for the first committed step in the biosynthesis of phorbol esters (PE) in the Euphorbiaceae. PE are abundant in the seeds of the biofuel crop Jatropha curcas and its toxicity precludes the use of the ...
Natália Pinto de Almeida   +6 more
doaj   +1 more source

Selected reaction monitoring for quantitative proteomics: a tutorial

open access: yesMolecular Systems Biology, 2008
Systems biology relies on data sets in which the same group of proteins is consistently identified and precisely quantified across multiple samples, a requirement that is only partially achieved by current proteomics approaches.
Vinzenz Lange   +3 more
doaj   +1 more source

Application of Selected Reaction Monitoring Mass Spectrometry to Field Grown Crop Plants To Allow Dissection of the Molecular Mechanisms of Abiotic Stress Tolerance.

open access: yesFrontiers in Plant Science, 2013
One major constraint upon the application of molecular crop breeding approaches is the small number of genes linked to agronomically desirable traits through defined biochemical mechanisms.
Richard P. Jacoby   +2 more
doaj   +1 more source

Regulation of yeast central metabolism by enzyme phosphorylation

open access: yesMolecular Systems Biology, 2012
As a frequent post‐translational modification, protein phosphorylation regulates many cellular processes. Although several hundred phosphorylation sites have been mapped to metabolic enzymes in Saccharomyces cerevisiae, functionality was demonstrated for
Ana Paula Oliveira   +5 more
doaj   +1 more source

Targeted proteomics reveals compositional dynamics of 60S pre‐ribosomes after nuclear export

open access: yesMolecular Systems Biology, 2012
Construction and intracellular targeting of eukaryotic pre‐ribosomal particles involve a multitude of diverse transiently associating trans‐acting assembly factors, energy‐consuming enzymes, and transport factors.
Martin Altvater   +7 more
doaj   +1 more source

Parallel Reaction Monitoring Mass Spectrometry for Rapid and Accurate Identification of β-Lactamases Produced by Enterobacteriaceae

open access: yesFrontiers in Microbiology, 2022
The increasing spread of drug-resistant bacterial strains presents great challenges to clinical antibacterial treatment and public health, particularly with regard to β-lactamase-producing Enterobacteriaceae.
Yun Lu   +7 more
doaj   +1 more source

Targeted Quantification of Protein Phosphorylation and Its Contributions towards Mathematical Modeling of Signaling Pathways

open access: yesMolecules, 2023
Post-translational modifications (PTMs) are key regulatory mechanisms that can control protein function. Of these, phosphorylation is the most common and widely studied.
Panshak P. Dakup   +5 more
doaj   +1 more source

Mass Spectrometry-based Approaches to Understand the Molecular Basis of Memory

open access: yesFrontiers in Chemistry, 2016
The central nervous system is responsible for an array of cognitive functions such as memory, learning, language and attention. These processes tend to take place in distinct brain regions; yet, they need to be integrated to give rise to adaptive or ...
Arthur Henriques Pontes   +1 more
doaj   +1 more source

Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells

open access: yesCurrent Research in Immunology, 2020
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is involved in immune response, cancer progression, and Alzheimer's disease. However, an understanding of the mechanistic basis of its function in this wide spectrum of physiological and pathological ...
Mohd Moin Khan   +11 more
doaj   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed   +5 more
wiley   +1 more source

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