Results 91 to 100 of about 2,157,533 (280)

Genetic parameters and trends for production and reproduction traits of a Landrace herd in China

open access: yesJournal of Integrative Agriculture, 2016
The objectives of this study were to estimate the genetic parameters and the breeding progress in a Landrace herd in China, and to predict the potential benefits by applying new breeding technology.
Zhe ZHANG   +8 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Genetic algorithm feature selection resilient to increasing amounts of data imputation

open access: yesProceedings of the International Florida Artificial Intelligence Research Society Conference
This paper investigates the robustness of a genetic algorithm (GA) in feature selection across a dataset with increasing imputed missing values. Feature selection can be beneficial in predictive modeling to reduce computational costs and potentially ...
Maryam Kebari, Annie S Wu
doaj   +1 more source

Negative Frequency-Dependent Selection Is Frequently Confounding

open access: yesFrontiers in Ecology and Evolution, 2018
Persistent genetic variation within populations presents an evolutionary problem, as natural selection and genetic drift tend to erode genetic diversity.
Dustin Brisson
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Test-day milk yield as a selection criterion for dairy buffaloes (Bubalus bubalis Artiodactyla, Bovidae)

open access: yesGenetics and Molecular Biology, 2008
Due to the great demand for buffalo milk by-products the interest in technical-scientific information about this species is increasing. Our objective was to propose selection criteria for milk yield in buffaloes based on total milk yield, 305-day milk ...
Humberto Tonhati   +5 more
doaj   +1 more source

Genetic linkage and natural selection [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2010
The prevalence of recombination in eukaryotes poses one of the most puzzling questions in biology. The most compelling general explanation is that recombination facilitates selection by breaking down the negative associations generated by random drift (i.e. Hill–Robertson interference, HRI). I classify the effects of HRI owing to: deleterious mutation,
openaire   +2 more sources

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