Results 91 to 100 of about 529,543 (309)

Balancing selection and its effects on sequences in nearby genome regions. [PDF]

, 2006
Our understanding of balancing selection is currently becoming greatly clarified by new sequence data being gathered from genes in which polymorphisms are known to be maintained by selection.
Deborah Charlesworth, Charlesworth Deborah, Charlesworth, Deborah   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sexual selection in a simultaneous hermaphrodite : mate choice and sperm utilization patterns [PDF]

, 2011
Sexual selection processes, in general, are distinguished in precopulatory and postcopulatory mechanisms. In the animal kingdom, precopulatory mechanisms are related to mate competition and mate choice before the copulation.
Kupfernagel, Sandra
core   +1 more source

Evaluating variable selection methods for multivariable regression models: A simulation study protocol.

PLoS ONE
Researchers often perform data-driven variable selection when modeling the associations between an outcome and multiple independent variables in regression analysis.
Theresa Ullmann, Georg Heinze, Lorena Hafermann, Christine Schilhart-Wallisch, Daniela Dunkler, for TG2 of the STRATOS initiative   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Response to somatic cell count-based selection for mastitis resistance in a divergent selection experiment in sheep [PDF]

, 2009
A divergent selection experiment in sheep was implemented to study the consequences of log-transformed somatic cell score (SCS)-based selection on resistance to natural intramammary infections.
Aurel, Marie-Rose, Bergonier, Dominique, Foucras, Gilles, Hygonenq, Marie Claude, Robert Granié, Christèle, Dion, Stéphane, Hygonenq, Marie-Claude, Robert-Granié, Christèle, Rupp, Rachel   +8 more
core   +1 more source

Fluctuating selection models and McDonald-Kreitman type analyses.

PLoS ONE, 2014
It is likely that the strength of selection acting upon a mutation varies through time due to changes in the environment. However, most population genetic theory assumes that the strength of selection remains constant.
Toni I Gossmann, David Waxman, Adam Eyre-Walker   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Variation in selection and its evolutionary consequences

, 2019
It is widely appreciated that many aspects of selection change temporally when populations experience stochastic environments. However, the long term consequences for adaptive evolution has received less consideration.
Hunter, Darren Clarke
core   +1 more source

[Selection by consequences].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1992
Selection made on the basis of consequences is a causal mode found only in "living" things. Selection happens at the level of species, individual and culture. Human behaviour is the joint product of the contingencies of existence responsible for natural selection and of contingencies by which the behaviour of individuals are selected, including the ...
openaire   +1 more source