Results 111 to 120 of about 529,543 (309)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Think-Aloud Protocols and the Selection Task: Evidence for Relevance Effects and Rationalization Processes. [PDF]

, 2005
Two experiments are reported that employed think-aloud methods to test predictions concerning relevance effects and rationalization processes derivable from Evans’ (1996) heuristic-analytic theory of the selection task.
Lucas, Erica J., Ball, Linden J., Lucas, EJ, Ball, LJ   +3 more
core   +1 more source

Adverse Consequences of Adverse Selection [PDF]

Journal of Health Politics, Policy and Law, 1999
M, Pauly, S, Nicholson
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Recent and Ancient Signature of Balancing Selection around the S-Locus in Arabidopsis halleri and A. lyrata [PDF]

, 2013
Balancing selection can maintain different alleles over long evolutionary times. Beyond this direct effect on the molecular targets of selection, balancing selection is also expected to increase neutral polymorphism in linked genome regions, in inverse ...
Ruggiero, Maria-Valeria, Roux, Camille, Pauwels, M., Roux, Clément, Castric, Vincent, Vekemans, X., Pauwels, Maxime, M.-V., Ruggiero, Charlesworth, D., Vekemans, Xavier, Charlesworth, Deborah   +10 more
core   +1 more source

Cultivating a Thriving Workforce in Hospitality Organisations - An Empirical Study of Its Antecedents and Consequences

Kvalita Inovácia Prosperita
Purpose: This paper focuses on cultivating employees’ experience of thriving at work (TAW) within the context of hospitality organisations. Specifically, it conceptualises and empirically tests a selection of antecedents to employees' TAW, as well as ...
Anette Knutsen Finstad, Barbara Rebecca Mutonyi, Terje Slåtten   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Temporal and spatial heterogeneity in dispersal and demography of a long‐lived philopatric seabird

Ecosphere
Individuals make habitat selection decisions at different moments of their life and in heterogeneous habitats. Understanding the links between environmental changes and demographic patterns during the individuals' life is therefore critical to predict ...
Ana Payo‐Payo, Andreu Rotger, Virginia Picorelli, Mariana Viñas Torres, Esteban Cardona, Oliver Martínez, Ana Sanz‐Aguilar   +6 more
doaj   +1 more source