Results 31 to 40 of about 2,744,010 (247)

Evidence of positive selection towards Zebuine haplotypes in the BoLA region of Brangus cattle

Animal, 2018
The Brangus breed was developed to combine the superior characteristics of both of its founder breeds, Angus and Brahman. It combines the high adaptability to tropical and subtropical environments, disease resistance, and overall hardiness of Zebu cattle
D.E. Goszczynski, C.M. Corbi-Botto, H.M. Durand, A. Rogberg-Muñoz, S. Munilla, P. Peral-Garcia, R.J.C. Cantet, G. Giovambattista   +7 more
doaj   +1 more source

Assessing Genomic Diversity and Productivity Signatures in Dianzhong Cattle by Whole-Genome Scanning

Frontiers in Genetics, 2021
Dianzhong cattle is a classic Chinese indigenous cattle breed with historical records dating back to 200 BC. But with its genomic differences having not been clearly elucidated, the quest for genomic characterization will be an essential step towards ...
Xianfu Zhang, Kaixing Qu, Peng Jia, Jicai Zhang, Jianyong Liu, Chuzhao Lei, Bizhi Huang   +6 more
doaj   +1 more source

Positive Selection in East Asians for an EDAR Allele that Enhances NF-κB Activation [PDF]

, 2008
Genome-wide scans for positive selection in humans provide a promising approach to establish links between genetic variants and adaptive phenotypes.
Hughes, David, Myles, Sean, Strotmann, Rainer, Stoneking, M. ; https://orcid.org/, Hughes, D., Pugach, Irina, Hardouin, Emilie, Stajich, Jason E., Jarosław Bryk, Pugach, I., Sean Myles, Hughes, D. ; https://orcid.org/, Jarosław Bryk, Mark Stoneking, Stoneking, Mark, Myles, S., Bryk, J., Bryk, Jarosław, Stoneking, M., Bryk, Jarek, Emilie Hardouin, Hughes, David A., Hardouin, E., Pugach, I. ; https://orcid.org/, Rainer Strotmann, Hardouin, E. ; https://orcid.org/, Myles, S. ; https://orcid.org/, Irina Pugach, David Hughes, Hardouin, E.A., Strotmann, R.   +30 more
core   +1 more source

Model selection and robust inference of mutational signatures using Negative Binomial non-negative matrix factorization

BMC Bioinformatics, 2023
Background The spectrum of mutations in a collection of cancer genomes can be described by a mixture of a few mutational signatures. The mutational signatures can be found using non-negative matrix factorization (NMF).
Marta Pelizzola, Ragnhild Laursen, Asger Hobolth   +2 more
doaj   +1 more source

Genomic Regions and Candidate Genes Linked to Capped Hock in Pig

Life, 2021
Capped hock affects the exterior of pedigree pigs, making them unsalable and resulting in a negative impact on the efficiency of pig-breeding centers.
Lyubov Getmantseva, Maria Kolosova, Faridun Bakoev, Anna Zimina, Siroj Bakoev   +4 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Linkage Disequilibrium, Haplotype Block Structures, Effective Population Size and Genome-Wide Signatures of Selection of Two Conservation Herds of the South African Nguni Cattle

Animals, 2022
The Nguni cattle of South Africa are a Sanga breed, characterized by many eco-types and research populations that have been established in an effort to conserve the diversity within the breed.
Njabulo M. Dlamini, Edgar F. Dzomba, Mpumelelo Magawana, Sphamandla Ngcamu, Farai C. Muchadeyi   +4 more
doaj   +1 more source

Assessing Population Structure and Signatures of Selection in Wanbei Pigs Using Whole Genome Resequencing Data

Animals, 2022
Wanbei pig (WBP) is one of the indigenous pig resources in China and has many germplasm characteristics. However, research on its genome is lacking. To assess the genomic variation, population structure, and selection signatures, we resequenced 18 WBP ...
Wei Zhang, Linqing Liu, Mei Zhou, Shiguang Su, Lin Dong, Xinxin Meng, Xueting Li, Chonglong Wang   +7 more
doaj   +1 more source