Results 81 to 90 of about 191,946 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Selective sweep analysis reveals extensive parallel selection traits between large white and Duroc pigs

Evolutionary Applications, 2020
In the process of pig genetic improvement, different commercial breeds have been bred for the same purpose, improving meat production. Most of the economic traits, such as growth and fertility, have been selected similarly despite the discrepant ...
Saixian Zhang, Kaili Zhang, Xia Peng, Huiwen Zhan, Jiahui Lu, Shengsong Xie, Shuhong Zhao, Xinyun Li, Yunlong Ma   +8 more
doaj   +1 more source

Identification of selection signatures and genetic diversity in the sheep. [PDF]

Trop Anim Health Prod
Abstract In the study, data obtained from OvineSNP50K SNP chips using the Illumina® iScan platform for Eşme sheep were used. The integrated haplotype score (iHS) and runs of homozygosity (ROH) statistical approaches were used to identify selection signatures.
Karabaş M, Yılmaz O.
europepmc   +3 more sources

Signatures of selection in tilapia revealed by whole genome resequencing [PDF]

, 2015
Natural selection and selective breeding for genetic improvement have left detectable signatures within the genome of a species. Identification of selection signatures is important in evolutionary biology and for detecting genes that facilitate to ...
Jing, Wu, Lin, Haoran, Meng, Zining, Bai, Zhiyi, Wang, Le, Li, Jiale, Xia, Jun Hong, Liu, Feng, Yue, Gen Hua, Zhang, Yong, Wan, Zi Yi   +10 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Selection signatures and landscape genomics analysis to reveal climate adaptation of goat breeds

BMC Genomics
Goats have achieved global prominence as essential livestock since their initial domestication, primarily owing to their remarkable adaptability to diverse environmental and production systems.
Weifeng Peng, Yiyuan Zhang, Lei Gao, Wanlu Shi, Zi Liu, Xinyu Guo, Yunxia Zhang, Bing Li, Guoyin Li, Jingya Cao, Mingsheng Yang   +10 more
doaj   +1 more source

Genomic Uniqueness of Local Sheep Breeds From Morocco

Frontiers in Genetics, 2021
Sheep farming is a major source of meat in Morocco and plays a key role in the country’s agriculture. This study aims at characterizing the whole-genome diversity and demographic history of the main Moroccan sheep breeds, as well as to identify selection
Abdessamad Ouhrouch, Abdessamad Ouhrouch, Simon Boitard, Frédéric Boyer, Bertrand Servin, Anne Da Silva, François Pompanon, Abdelmajid Haddioui, Badr Benjelloun   +8 more
doaj   +1 more source

Signatures of Selection for Intramuscular Fat in Duroc Pigs [PDF]

, 2015
Intramuscular fat (IMF) content is an important trait affecting the quality of pork. Two Duroc populations (Iowa and Spain) selected for IMF were used to identify signatures of selection associated with IMF. The effects of selection were analyzed between
Kim, Eui-Soo, Ros-Frixedes, Roger, Baas, Thomas, Estany, Joan, Rothschild, Max   +4 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Runs of homozygosity in Italian Holstein bulls: a permutation approach and time-based mapping of the genomic regions potentially under selection

BMC Genomics
Background Runs of homozygosity (ROH) occurrence in animal genomes may result from a high level of relatedness within the population or from positive selection.
Laura Falchi, Alberto Cesarani, Luiz F. Brito, Salvatore Mastrangelo, Alfredo Pauciullo, Nicolò P. P. Macciotta, Giustino Gaspa   +6 more
doaj   +1 more source