Results 301 to 310 of about 166,195 (340)

α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy. [PDF]

Cell Res
Xu Q, Wang H, Yang R, Tao Y, Wang Z, Zhang S, Sun B, Li D, Lu B, Liu C.   +9 more
europepmc   +1 more source

GFAP Degradation via Selective Autophagy Enhancement Using PROTAC-Mediated p62/SQSTM1 Stabilization

MedicOath Autonomous Discovery Engine
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S-acylation regulates SQSTM1/p62-mediated selective autophagy. [PDF]

Autophagy
Huang X, Liu L, Yao J, Lin C, Xiang T, Yang A.   +5 more
europepmc   +1 more source

Thyroid Hormone-Mediated Selective Autophagy and Its Implications in Countering Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Endocrinol Metab (Seoul)
Sinha RA.
europepmc   +1 more source

Autophagy selectively clears ER in TNF-α-induced muscle atrophy

Ursula K. Dueren, Alan An Jung Wei, A. Elisabeth Gressler, Simon Rapp, Oliver Popp, Robert Kerridge, Viviana Buonomo, Paolo Grumati, Philipp Mertins, Matthias Selbach, Anna Katharina Simon, Thomas Sommer   +11 more
openalex   +1 more source

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Selective autophagy

Essays in Biochemistry, 2013
During the last decade it has become evident that autophagy is not simply a non-selective bulk degradation pathway for intracellular components. On the contrary, the discovery and characterization of autophagy receptors which target specific cargo for lysosomal degradation by interaction with ATG8 (autophagy-related protein 8)/LC3 (light-chain 3) has ...
Steingrim, Svenning, Terje, Johansen
openaire   +2 more sources

Hitchhiking on selective autophagy

Nature Cell Biology, 2018
Selective autophagy is important for controlled degradation of cellular components. However, a selective autophagic degradation mechanism for ribosomes in mammals has remained unclear. A study now describes non-selective and selective ribosome degradation and a significant role for ‘bystander’ non-selective autophagy.
Christian, Münch, Ivan, Dikic
openaire   +2 more sources

Huntingtin facilitates selective autophagy

Nature Cell Biology, 2015
Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.
Amir, Gelman, Moran, Rawet-Slobodkin, Zvulun, Elazar   +2 more
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Membrane recruitment of autophagy proteins in selective autophagy

Hepatology Research, 2012
Autophagy is a stress response that is upregulated in response to signals such as starvation, growth factor deprivation, endoplasmic reticulum stress, and pathogen infection. Defects in this pathway are the underlying cause of a number of diseases, including metabolic aberrations, infectious diseases, and cancer, which are closely related to hepatic ...
Eiji, Morita, Tamotsu, Yoshimori
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Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy

Cell Biochemistry and Function, 2019
The ataxia‐telangiectasia mutated (ATM) protein kinase is best known for its critical nuclear roles in the DNA damage response (DDR), cell cycle checkpoints, and the maintenance of gene stability. In this review, we highlight the multifaceted cytoplasmic functions of ATM in autophagy.
Nan Liang, Qiao He, Xiaodong Liu, Hui Sun   +3 more
openaire   +2 more sources