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Function of Atg11 in non-selective autophagy and selective autophagy of Candida albicans
Biochemical and Biophysical Research Communications, 2019Candida albicans is an important opportunistic pathogenic fungus in the human body. It is a common microbe inhabiting on the mucosa surfaces of healthy individuals, but may cause infections when the host immune system is weak. Autophagy is a "self-eating" process in eukaryotes, which can recover and utilize damaged organelles and misfolded proteins ...
Lifang Cui +7 more
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Selective autophagy goes exclusive
Nature Cell Biology, 2014Using in vitro reconstitution systems, three studies shed light on the interactions of Atg8 family proteins with cargo receptors and components of the basal autophagy machinery. The results have important mechanistic implications for selective macroautophagy, scaffold formation and spatio-temporal organization of the lipidation process during ...
Terje Johansen, Trond Lamark
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Selective degradation of p62 by autophagy
Seminars in Immunopathology, 2010The autophagy-lysosome pathway is a highly conserved bulk degradation system in eukaryotes. During starvation, cytoplasmic constituents are non-selectively degraded by autophagy, and the resulting amino acids are utilized for cell survival. By taking advantage of mouse genetics, many physiological functions of mammalian autophagy have been uncovered ...
Yoshinobu, Ichimura, Masaaki, Komatsu
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Seminars in cell biology, 1991
Autophagy is the major process by which cells degrade their own cytoplasm. Autophagy begins with the sequestration of a portion of the cytoplasm by a membraneous organelle called a phagophore. The resulting vacuole (autophagosome) can fuse with an endocytic vacuole to form am amphisome, which subsequently fuses with a lysosome to have its mixed ...
P O, Seglen, P B, Gordon, I, Holen
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Autophagy is the major process by which cells degrade their own cytoplasm. Autophagy begins with the sequestration of a portion of the cytoplasm by a membraneous organelle called a phagophore. The resulting vacuole (autophagosome) can fuse with an endocytic vacuole to form am amphisome, which subsequently fuses with a lysosome to have its mixed ...
P O, Seglen, P B, Gordon, I, Holen
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Selective Autophagy and Cancer
2013In normal cells, autophagy prevents tumorigenesis through selective cleanup of damaged organelles and certain specific proteins such as p62. In contrast, autophagy provides tumor cells, which require enormous amounts of nutrients, with amino acids, fatty acids, and glucose. Therefore, autophagy represents something of a double-edged sword in cancer: it
Yoshinobu Ichimura, Masaaki Komatsu
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The mechanisms and roles of selective autophagy in mammals
Nature Reviews Molecular Cell Biology, 2022Jose Norberto S Vargas +2 more
exaly
Molecular Mechanisms of Selective Autophagy
Journal of Molecular Biology, 2020Martens, Sascha, Behrends, Christian
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Autophagy and autophagy-related pathways in cancer
Nature Reviews Molecular Cell Biology, 2023Jayanta Debnath +2 more
exaly
SELECTİVE AUTOPHAGY AND SUBTYPES
2018Otofajihücresel metabolizmanın düzenlenmesi, yaşlanma, morfogenez, pek çok hastalığıngelişmesi ve bağışıklığın düzenlenmesi gibi fizyolojik süreçlerde anahtar rolüstlenmektedir. Otofajinin temel tetikleyicisinin besin azlığı olduğununbilinmesinin yanında, farklı hastalık süreçlerinde, çeşitli tetikleyiciler vedüzenleyiciler tarafından kontrol edildiği ...
FIRAT, Fatma, ÖZBİLGİN, Kemal
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