Results 71 to 80 of about 78,923 (333)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

CO2 Hydrogenation to Formate and Formic Acid by Bimetallic Palladium-Copper Hydride Clusters. [PDF]

, 2020
Mass spectrometric analysis of the anionic products of interaction between bimetallic palladium-copper tetrahydride anions, PdCuH4-, and carbon dioxide, CO2, in a reaction cell shows an efficient generation of the PdCuCO2H4- intermediate and formate ...
Alexandrova, Anastassia N, Blankenhorn, Moritz, Bowen, Kit H, Liu, Gaoxiang, Marshall, Mary, Poths, Patricia, Zhang, Xinxing, Zhu, Zhaoguo   +7 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

An In Situ Surface-Enhanced Infrared Absorption Spectroscopy Study of Electrochemical CO2 Reduction: Selectivity Dependence on Surface C-Bound and O-Bound Reaction Intermediates

, 2019
The CO_{2} electro-reduction reaction (CORR) is a promising avenue to convert greenhouse gases into high-value fuels and chemicals, in addition to being an attractive method for storing intermittent renewable energy.
Andreussi, Oliviero, Giordano, Livia, Hwang, Jonathan, Katayama, Yu, Marzari, Nicola, Nattino, Francesco, Rao, Reshma R., Shao-Horn, Yang   +7 more
core   +1 more source

The Liquid Phase Catalytic Hydrogenation of the Furfural to Furfuryl Alcohol

Chemical Engineering Transactions, 2018
The results of the study of palladium catalysts in the selective hydrogenation of furfural to furfural alcohol are presented. A comparison of the properties of palladium catalytic systems prepared on different supports (aluminium oxide, hypercrosslinked ...
Kseniya Salnikova, Valentina Matveeva, Alexey Bykov, Galina Demidenko, Irina Shkileva, Esther Sulman   +5 more
doaj   +1 more source

BNPd single-atom catalysts for selective hydrogenation of acetylene to ethylene: a density functional theory study [PDF]

Royal Society Open Science, 2018
The mechanisms of selective hydrogenation of acetylene to ethylene on B11N12Pd single-atom catalyst were investigated through the density functional theory by using the 6-31++G** basis set.
Wanqi Gong, Lihua Kang
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Iridium(I) NHC/phosphine catalysts for mild and chemoselective hydrogenation processes [PDF]

, 2016
The directed, chemoselective hydrogenation of olefins has been established using iridium(I) catalysts which feature a tuned NHC/phosphine ligand combination.
Atzrodt, Bennie, Brinkman, Brown, Brown, Cochrane, Constable, Crabtree, Crabtree, Crabtree, Del Valle, Horváth, Hoveyda, Kavanagh, Kerr, Kerr, Kerr, Lee, Osborn, Rylander, Rylander, Stork, Tucker, Vázquez-Serrano, Vázquez-Serrano, Wüstenberg, Young, Zhu   +27 more
core   +1 more source

Silica-supported PdGa Nanoparticles: Metal Synergy for Highly Active and Selective CO2-to-CH3OH Hydrogenation [PDF]

, 2021
Scott R. Docherty, Nat Phongprueksathat, Erwin Lam, Gina Noh, Оlga V. Safonova, Atsushi Urakawa, Christophe Copéret   +6 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source