Results 71 to 80 of about 1,055,415 (308)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Elucidating the structure-activity relationship of the bimetallic Ni-Cu catalysts for CO2 hydrogenation

Journal of CO2 Utilization
The conversion of carbon dioxide (CO2) into high-value products plays a critical role in mitigating atmospheric CO2 levels. Recently, low-cost Ni-based catalysts have been garnering attention due to their exceptional hydrogenation ability.
Yifei Feng, Liang Shen, Wenhao Zhang, Xiaohan Yuan, Minghui Zhu, Jing Xu   +5 more
doaj   +1 more source

Optimizing reaction paths for methanol synthesis from CO2 hydrogenation via metal-ligand cooperativity

Nature Communications, 2019
Controlling the reaction path is instrumental for developing efficient catalysts for CO2 hydrogenation. Here, the authors report that the ensemble of Pt single atoms coordinated with oxygen atoms in MIL-101 induces distinct reaction path to improve ...
Yizhen Chen, Hongliang Li, Wanghui Zhao, Wenbo Zhang, Jiawei Li, Wei Li, Xusheng Zheng, Wensheng Yan, Wenhua Zhang, Junfa Zhu, Rui Si, Jie Zeng   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Liquid Phase Catalytic Hydrogenation of the Furfural to Furfuryl Alcohol

Chemical Engineering Transactions, 2018
The results of the study of palladium catalysts in the selective hydrogenation of furfural to furfural alcohol are presented. A comparison of the properties of palladium catalytic systems prepared on different supports (aluminium oxide, hypercrosslinked ...
Kseniya Salnikova, Valentina Matveeva, Alexey Bykov, Galina Demidenko, Irina Shkileva, Esther Sulman   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Reações de hidrogenação e isomerização de olefinas utilizando nanopartículas de paládio estabilizadas por um surfactante dipolar iônico baseado no anel imidazol [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-graduação em Química, Florianópolis, 2014O presente trabalho descreve a preparação de dois catalisadores baseados em nanopartículas
Leopoldino, Elder Correa
core  

Selective hydrogenation of benzene to cyclohexene over colloidal ruthenium catalyst stabilized by silica

, 2006
A colloidal ruthenium catalyst stabilized by silica was prepared through microemulsion processing. Ruthenium colloids with particle size about 4 nm are highly dispersed in silica. The selective hydrogenation of benzene to cyclohexene was studied over the
Liu, J, Xu, J, 徐杰, Lu, F, Ning, JB
core   +1 more source

Model arenes hydrogenation with silica-supported rhodium nanoparticles:The role of the silica grains and of the solvent on catalytic activities [PDF]

, 2009
Silica-supported rhodium-based nanoheterogeneous catalysts were easily prepared by impregnation with a pre-stabilized colloidal suspension. The resulting catalysts contain rhodium nanoparticles well-dispersed in the silica pores with a mean size of 5 nm.
Philippot, Karine, Hemati, Mehrdji, Chaudret, Bruno, Denicourt-Nowicki, A., Roucoux, Alain, Denicourt-Nowicki, Audrey, Barthe, Laurie   +6 more
core   +1 more source