Results 71 to 80 of about 24,483 (311)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Optimizing reaction paths for methanol synthesis from CO2 hydrogenation via metal-ligand cooperativity

Nature Communications, 2019
Controlling the reaction path is instrumental for developing efficient catalysts for CO2 hydrogenation. Here, the authors report that the ensemble of Pt single atoms coordinated with oxygen atoms in MIL-101 induces distinct reaction path to improve ...
Yizhen Chen, Hongliang Li, Wanghui Zhao, Wenbo Zhang, Jiawei Li, Wei Li, Xusheng Zheng, Wensheng Yan, Wenhua Zhang, Junfa Zhu, Rui Si, Jie Zeng   +11 more
doaj   +1 more source

Supported Bimetallic AuPd Nanoparticles as a Catalyst for the Selective Hydrogenation of Nitroarenes

Nanomaterials, 2018
The solvent-free selective hydrogenation of nitrobenzene was carried out using a supported AuPd nanoparticles catalyst, prepared by the modified impregnation method (MIm), as efficient catalyst >99% yield of aniline (AN) was obtained after 15 h at 90 &
Ruiyang Qu, Margherita Macino, Sarwat Iqbal, Xiang Gao, Qian He, Graham John Hutchings, Meenakshisundaram Sankar   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Elucidating the structure-activity relationship of the bimetallic Ni-Cu catalysts for CO2 hydrogenation

Journal of CO2 Utilization
The conversion of carbon dioxide (CO2) into high-value products plays a critical role in mitigating atmospheric CO2 levels. Recently, low-cost Ni-based catalysts have been garnering attention due to their exceptional hydrogenation ability.
Yifei Feng, Liang Shen, Wenhao Zhang, Xiaohan Yuan, Minghui Zhu, Jing Xu   +5 more
doaj   +1 more source

Z -Selective alkyne semi-hydrogenation catalysed by piano-stool N -heterocyclic carbene iron complexes

, 2018
Piano-stool NHC iron complexes catalyze the selective semi-hydrogenation of alkynes without any over-reduction and with high selectivity towards Z-alkynes when starting from disubstituted alkynes.
Albrecht, Martin, Martin Albrecht, Chloe Johnson, Johnson, Chloë   +3 more
core   +1 more source

In Situ-Formed Cobalt Nanoparticles Embedded Within Carbonaceous Matrix as Highly Efficient and Selective Catalysts for the Hydrogenation of Nitroarenes

, 2021
Inhibiting the side reactions (such as dehalogenation) while promoting both/transfer hydrogenation are the main target for the production of functional anilines from nitroarenes; consequently, the preparation of an ideal catalyst to improve reaction ...
Jianguo, Liu, Longlong, Ma, Shurong, Zhong, Xiuzheng, Zhuang, 修政, 庄   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

: Size‐Selective Hydrogenation Catalyst under Mild Conditions

, 2021
Fine-tuning hydrogenation: A thermally stable hydrogel nanocomposite has been prepared by charge-assisted self-assembly of Pd@ZIF-8 nanoparticles with Laponite® nanoclay.
Subhajit Laha, Suresh Babu Kalidindi, Tapas Kumar Maji, Sutar, Papri, Laha, Subhajit, Vasudeva Rao Bakuru, Yadav, Pooja, Maji, Tapas Kumar, Pooja Yadav, Kalidindi, Suresh Babu, Papri Sutar, Bakuru, Vasudeva Rao   +11 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source