Results 61 to 70 of about 219,982 (268)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Selective Oxidation of Zirconium in Zr2Cu
Croatica Chemica Acta, 1999 The high-temperature oxidation of Zr2Cu in dry oxygen is characterized by selective oxidation of zirconium. The excess of copper is accumulated in the matrix alloy at the alloy-oxide interface forming the Zr8Cu5 phase. The oxide layer consists of monoclinic ZrO2 and a small amount of CuO. Additionally, tetragonal ZrO2 appears up to 873 K at the surface,
Paljević, Matija, Tudja, Marijan
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Highly Active Oxygen Evolution Integrating with Highly Selective CO2-to-CO Reduction
Nano-Micro LettersHighlights Rational regulation of the coordination environment of surface-active sites on both photoanode and cathode has been demonstrated. Reducing the coordination of FeNi catalysts decorated on BiVO4 photoanodes achieves excellent water oxidation ...
Chaowei Wang, Laihong Geng, Yingpu Bi
doaj +1 more source
Hybridization of Particulate Methane Monooxygenase by Methanobactin-Modified AuNPs
Molecules, 2019 Particulate methane monooxygenase (pMMO) is a characteristic membrane-bound metalloenzyme of methane-oxidizing bacteria that can catalyze the bioconversion of methane to methanol.
Jia-Ying Xin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Recent advances in using carbon dioxide as a carbonyl source for carbonylation reactions
Sustainable Chemistry for Energy MaterialsCarbon dioxide (CO2) is an abundant, low-cost, and non-toxic C1 building block, and its valorization plays a pivotal role in achieving the goal of carbon neutrality.
Huixian Chen +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Epoxidation of Ethylene by Whole Cell Suspension of Methylosinus trichosporium IMV 3011
Journal of Chemistry, 2017 Methane monooxygenase (MMO) has been found in methanotrophic bacteria, which catalyzes the epoxidation of gaseous alkenes to their corresponding epoxides.
Jia-Ying Xin +4 more
doaj +1 more source