Results 141 to 150 of about 7,245 (254)

Menopause and vascular endothelial health: Is it all about the oestrogen?

Experimental Physiology, EarlyView.
Abstract Cardiovascular disease (CVD) is a leading cause of mortality in women, and CVD risk is accelerated during the menopause transition. This acceleration has traditionally been attributed to the hallmark decline in oestradiol with menopause. However, the menopause transition is also characterized by changes in other sex hormones that exert effects
Virginia R. Nuckols, Allyson I. Schwab, Lyndsey E. DuBose, Kerrie L. Moreau, Megan M. Wenner   +4 more
wiley   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models

Experimental Physiology, EarlyView.
Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar, Seval Ulku Orhan, Cigdem Tekin, Asli Taslidere, Mete Ozcan, Suat Tekin   +5 more
wiley   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Human placental exposure to pollutant nanoparticles: uptake, translocation and functional impact

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to pollutant nanoparticles has been increasingly investigated due to concerns about their potential effects on placental function and pregnancy outcomes. Maternal inhalation of pollutant nanoparticles can result in a pro‐inflammatory response; particles can also translocate across the alveolus epithelial barrier
Katherine L. Bethell, Andrew C. Povey, Edward D. Johnstone, Peter T. Ruane   +3 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Abcc1 deficiency protects from corticosterone but not cortisol‐induced adiposity and insulin resistance in a sex‐specific manner

The Journal of Physiology, EarlyView.
Abstract figure legend A mouse model of exogenous glucocorticoid (GC) treatment was used to determine (1) if corticosterone induced the same metabolic dysregulation as cortisol, and (2) whether these differences were mediated by the corticosterone‐specific transmembrane exporter Abcc1.
Mhairi A. Paul, Boglarka Nagy, Sofia Laforest, Joanna P. Simpson, William Mungall, Natalie Z. M. Homer, Robert K. Semple, Ruth Andrew, Roland H. Stimson, Mark Nixon   +9 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source