Results 11 to 20 of about 7,245 (254)

90 YEARS OF PROGESTERONE: Selective progesterone receptor modulators in gynaecological therapies [PDF]

Journal of Molecular Endocrinology, 2020
Abnormal uterine bleeding (AUB) is a chronic, debilitating and common condition affecting one in four women of reproductive age. Current treatments (conservative, medical and surgical) may be unsuitable, poorly tolerated or may result in loss of fertility.
Critchley, Hilary O.D., Chodankar, Rohan
openaire   +2 more sources

Selective progesterone receptor modulators (SPRMs) for uterine fibroids [PDF]

Cochrane Database of Systematic Reviews, 2017
Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment.
Ally, Murji, Lucy, Whitaker, Tiffany L, Chow, Mara L, Sobel   +3 more
openaire   +2 more sources

Effect of combining CBD with standard breast cancer therapeutics

Advances in Cancer Biology - Metastasis, 2022
Breast cancer is the most common malignancy in women worldwide. Sixty-five percent of breast cancers are estrogen and/or progesterone receptor positive.
Luka Dobovišek, Metka Novak, Fran Krstanović, Simona Borštnar, Tamara Lah Turnšek, Nataša Debeljak   +5 more
doaj   +1 more source

POSSIBILITIES TO APPLY PROGESTERONE RECEPTOR SELECTIVE MODULATORS IN WOMEN OF REPRODUCTIVE AGE WITH UTERINE MYOMA

Медицинский совет, 2016
Uterine myoma is the most common benign monoclonal tumor. The frequency of uterine myoma is 20–35%  in women of reproductive age and reaches 70% after the age of 50. Modern strategy of treatment of uterine myomas are largely individualized and depends on
G. E. Chernukha, M. R. Dumanovskaya, G. I. Tabeeva   +2 more
doaj   +1 more source

Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl2-L1 Expression. [PDF]

PLoS ONE, 2015
The progesterone receptor (PR) with its isoforms and ligands are involved in breast tumorigenesis and prognosis. We aimed at analyzing the respective contribution of PR isoforms, PRA and PRB, in breast cancer cell proliferation in a new estrogen ...
Nathalie Esber, Florian Le Billan, Michèle Resche-Rigon, Hugues Loosfelt, Marc Lombès, Nathalie Chabbert-Buffet   +5 more
doaj   +1 more source

Current practices for treatment of uterine fibroids

Journal of Mid-Life Health, 2017
The treatment of uterine fibroids depends on symptoms of patients, size of the fibroid, desire for future pregnancy, and preference of the treating gynecologist.
Shalini Singh, Tanmay Thulkar, Monisha Pawanarkar, Jyoti Thulkar   +3 more
doaj   +1 more source

Non-surgical treatment of uterine fibroids. Efficacy of the selective progesterone receptor modulator

Медицинский совет, 2019
The leading role of ovarian steroid hormones in the pathogenesis of uterine fibroids is confirmed by epidemiological, clinical and experimental studies.
E. R. Dovletkhanova, E. A. Mezhevitinova, V. N. Prilepskaya   +2 more
doaj   +1 more source

Ligand Binding Induces Agonistic-Like Conformational Adaptations in Helix 12 of Progesterone Receptor Ligand Binding Domain

Frontiers in Chemistry, 2019
Progesterone receptor (PR) is a member of the nuclear receptor (NR) superfamily and plays a vital role in the female reproductive system. The malfunction of it would lead to several types of cancers.
Liangzhen Zheng, Kelin Xia, Kelin Xia, Yuguang Mu, Yuguang Mu   +4 more
doaj   +1 more source

Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility

Endocrine Reviews, 2020
AbstractSelective progesterone receptor modulators (SPRMs) are a new class of compounds developed to target the progesterone receptor (PR) with a mix of agonist and antagonist properties. These compounds have been introduced for the treatment of several gynecological conditions based on the critical role of progesterone in reproduction and reproductive
Md Soriful Islam, Sadia Afrin, Sara Isabel Jones, James Segars   +3 more
openaire   +3 more sources

Ulipristal acetate for Japanese women with symptomatic uterine fibroids: A double‐blind, randomized, phase II dose‐finding study

Reproductive Medicine and Biology, 2020
Purpose A multicenter, randomized, double‐blind, placebo‐controlled trial was conducted to evaluate the efficacy, safety, and appropriate dose of ulipristal acetate (UPA) in Japanese women with symptomatic uterine fibroids (UFs).
Minoru Irahara, Yasuhiro Maejima, Nobuhiro Shinbo, Yuji Yamauchi, Hideki Mizunuma   +4 more
doaj   +1 more source