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Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications [PDF]
Human Reproduction Update, 2005 Since the discovery of the antiprogestin mifepristone, hundreds of similar compounds have been synthesized, which can be grouped in a large family of progesterone receptor ligands. This family includes pure agonists such as progesterone itself or progestins and, at the other end of the biological spectrum, pure progesterone receptor antagonists (PA ...
Nathalie, Chabbert-Buffet +3 more
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Menopause Review, 2016 Uterine fibroids are found in almost 20-40% of women of reproductive age. For each woman an individualised treatment method should be applied because the hysterectomy procedure is not a good option in every case. The uterus is an organ necessary not only
Anita Olejek +2 more
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Репродуктивная эндокринология, 2017 Introduction: During the last decade, there has been increased emphasis on the role of progesterone in the promotion of fibroid growth, as well as heightened interest in modulating progesterone pathways by use of selective progesterone receptor ...
Jacques Donnez +2 more
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Effects of Combination of Estradiol with Selective Progesterone Receptor Modulators (SPRMs) on Human Breast Cancer Cells In Vitro and In Vivo. [PDF]
PLoS ONE, 2016 Use of estrogen or estrogen/progestin combination was an approved regimen for menopausal hormonal therapy (MHT). However, more recent patient-centered studies revealed an increase in the incidence of breast cancer in women receiving menopausal hormone ...
Hareesh B Nair +4 more
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Clocks & Sleep, 2022 While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia.
Alexandre González-Rodríguez +6 more
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Cells, 2021 Lysophosphatidic acid (LPA) induces a wide range of cellular processes and its signaling is increased in several cancers including glioblastoma (GBM), a high-grade astrocytoma, which is the most common malignant brain tumor. LPA1 receptor is expressed in
Silvia Anahi Valdés-Rives +8 more
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ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE
Сибирский онкологический журнал, 2020 Hormone-receptor positive breast cancer is the most common molecular subtype and represents 60–75 % of all breast cancers (BC). The presence of specific molecular targets such as the estrogen/progesterone receptor determines the use of hormone therapy ...
D. B. Erdyneeva +6 more
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Tamoxifen Induced Pancreatitis: An Unusual Complication of Commonly used Drug [PDF]
Journal of Clinical and Diagnostic Research, 2017 Tamoxifen is a selective oestrogen receptor modulator used for the treatment of oestrogen/progesterone receptor positive breast cancer. It possess antagonistic or agonistic activity depending on the tissue location i.e., antagonistic action on breast ...
Pritam Suresh Chandra Kataria +4 more
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Сибирский научный медицинский журнал, 2020 Aim of the study was to investigate the clinical features of reproductive age women with uterine body myoma and the production of vascular endothelial growth factor (VEGF) in the dominant myoma node and perifocal myometrium under the preoperative use of ...
I. O. Marinkin +7 more
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Viruses, 2021 Inherited chromosomally integrated (ici) human herpes virus 6 (HHV-6) is estimated to occur in 0.6–2.7% of people worldwide. HHV-6 comprises two distinct species: HHV-6A and HHV-6B. Both HHV-6A and HHV-6B integration have been reported. Several drugs are
Laure Izquierdo +6 more
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