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Treatment of symptomatic uterine leiomyomas with selective progesterone receptor modulators
Expert Review of Obstetrics & Gynecology, 2011Uterine leiomyomas, also known as fibroids, are benign tumors of both smooth muscle and connective tissue origin.
Dale W Stovall, Hana E Mikdachi
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Impact of selective progesterone receptor modulators (SPRMs) on the human endometrium
2023INTRODUCTION: Heavy menstrual bleeding (HMB) is a common, chronic, debilitating and often underreported condition affecting at least 1 in 4 women of reproductive age. There is an unmet for managing the symptom of HMB. Selective Progesterone Receptor Modulators (SPRMs) are a class of drugs that interact with the progesterone receptor (PR) in a mixed ...
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Promising selective progesterone receptor modulators: what’s new in female contraception?
Expert Opinion on Investigational DrugsSelective progesterone receptor modulators (SPRMs), such as mifepristone and ulipristal acetate (UPA), have demonstrated high efficacy and safety as single-dose treatments for medication abortion and emergency contraception (EC). Other obstetrical and gynecologic applications have emerged, both for episodic and ongoing uses.
Anita, Nelson, Marit Pearlman, Shapiro
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[Selective progesterone receptor modulators: future clinical applications].
Bulletin de l'Academie nationale de medecine, 2009Progesterone antagonists belong to the family of selective progesterone receptor modulators. SPRMs already have several applications in women's health. Their main value lies in their effect on endometrium. For example, they can be used to reduce tumor volume and uterine bleeding before uterine myoma surgery.
Philippe, Bouchard +2 more
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[The use of selective progesterone receptor modulators in the treatment of myomas].
Ceska gynekologie, 2017To summarize the knowledge of the effect of selective progesterone receptor modulators and their use in the treatment of myomas in women of childbearing age and in perimenopause.Review articleResults: Long-term treatment with ulipristal acetate maximizes its effectiveness, it helps to achieve faster bleeding control and increases the number of patients
O, Šimetka, J, Klát
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The place of selective progesterone receptor modulators in myoma therapy.
Minerva ginecologica, 2016Uterine fibroids are the most commonly encountered benign uterine tumors in women of reproductive age. As progesterone is known to play a key role in promoting myoma growth, the goal of the study was to analyze the efficacy of selective progesterone receptor modulators (SPRMs). From four studies, it was concluded that UPA (ulipristal acetate) treatment
J, Donnez +3 more
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Asoprisnil: A selective progesterone receptor modulator
Indian Journal of Pharmacology, 2005C Girish, M Jayanthi, G Sivaraman
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Progesterone Receptor Antagonists and Selective Progesterone Receptor Modulators (SPRMs)
Seminars in Reproductive Medicine, 2005openaire +2 more sources