Results 211 to 220 of about 7,245 (254)
Some of the next articles are maybe not open access.
Selective Progesterone Receptor Modulators for the Treatment of Uterine Leiomyomas
Obstetrics & Gynecology, 2017Uterine leiomyomas have drawn much attention since being described more than 200 years ago. These common benign uterine tumors often present with prolonged menstrual bleeding, pelvic pressure, and reproductive disorders and pose a true financial burden on health care systems all over the world.
Myriam, Safrai +3 more
openaire +2 more sources
Selective Progesterone Receptor Modulators (SPRMs)
Annals of the New York Academy of Sciences, 2002Abstract: Endometriosis, the presence of endometrial tissue outside the uterus, is a progressive, estrogen‐dependent disease and occurs nearly exclusively in menstruating women of reproductive age. Pain syndrome, however, represents the major clinical problem of this disease, manifested as dysmenorrhea, pelvic pain, lower abdominal pain, and ...
Kristof, Chwalisz +4 more
openaire +2 more sources
Selective progesterone receptor modulators: current applications and perspectives
Climacteric, 2018Selective progesterone receptor modulators (SPRMs) are steroid progesterone receptor ligands able to induce agonistic or antagonistic activities. Mifepristone, the class leader, was primarily used for pregnancy termination from the 1980s. Emergency contraception with extended activity was the second major development 30 years later, with mifepristone ...
N. Chabbert-Buffet +3 more
openaire +2 more sources
Selective progesterone receptor modulators 1: use during pregnancy
Expert Opinion on Pharmacotherapy, 2008A large number of synthetic compounds known as selective progesterone receptor modulators can bind to progesterone receptors: the ligands exhibit a spectrum of activities ranging from pure antagonism to a mixture of agonism and antagonism.Only a dozen or so selective progesterone receptor modulators have been tested to any significant extent: among ...
BENAGIANO, Giuseppe +2 more
openaire +3 more sources
Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis [PDF]
Endocrine Reviews, 2005 Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands. SPRMs exert clinically relevant tissue-selective progesterone agonist, antagonist, or mixed agonist/antagonist effects on various progesterone target tissues in vivo.
Maria Claudia Perez, W Elger
exaly +3 more sources
Selective progesterone receptor modulators 2: use in reproductive medicine
Expert Opinion on Pharmacotherapy, 2008Synthetic compounds can bind to progesterone receptors and these progesterone receptor ligands exhibit a spectrum of activities ranging from pure antagonism to a mixture of agonism and antagonism. These substances have been classified as antiprogestins or as selective progesterone receptor modulators.There are several hundred selective progesterone ...
BENAGIANO, Giuseppe +2 more
openaire +3 more sources
[Interest of selective progesterone receptor modulators in endometriosis].
Gynecologie, obstetrique & fertilite, 2014The SPRM (selective progesterone receptor modulators) are agonists and/or antagonists of progesterone receptor. They are responsible for anovulation, amenorrhea and a lower prostaglandin levels, which leads to an improvement in pain and regression of lesions in endometriosis.
P, Merviel +5 more
openaire +2 more sources
The Endocrinologist, 2005
Since the description of the structure of the first progesterone receptor antagonist, mifepristone, was published, numerous related compounds have been synthesized, which may function as progesterone receptor antagonists (PRAs) or selective progesterone receptor modulators (SPRMs).
openaire +1 more source
Since the description of the structure of the first progesterone receptor antagonist, mifepristone, was published, numerous related compounds have been synthesized, which may function as progesterone receptor antagonists (PRAs) or selective progesterone receptor modulators (SPRMs).
openaire +1 more source
Clinical Obstetrics & Gynecology, 2021
Common benign gynecologic conditions such as uterine fibroids and endometriosis are linked to chronic pelvic pain, abnormal and heavy uterine bleeding, and infertility. Effective medical management of these diseases is an unmet need. The steroid hormones progesterone (P4), estrogen (E2), and testosterone play a major role in reproductive physiology and
Md Soriful, Islam +2 more
openaire +2 more sources
Common benign gynecologic conditions such as uterine fibroids and endometriosis are linked to chronic pelvic pain, abnormal and heavy uterine bleeding, and infertility. Effective medical management of these diseases is an unmet need. The steroid hormones progesterone (P4), estrogen (E2), and testosterone play a major role in reproductive physiology and
Md Soriful, Islam +2 more
openaire +2 more sources
The potential of selective progesterone receptor modulators for the treatment of uterine fibroids
Expert Review of Endocrinology & Metabolism, 2013In addition to the estrogen receptor, the progesterone receptor plays an important role in the growth of uterine fibroids. Several selective progesterone receptor modulators (SPRMs) have been evaluated for medical treatment of uterine fibroids and, because of safety issues, some molecules were stopped during clinical development.
Elke, Bestel, Jacques, Donnez
openaire +2 more sources