Female genital disorder as adverse symptom of lamotrigine treatment - A serotoninergic effect? [PDF]
, 1998 The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake.
Amann, Benedikt +2 more
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Serotonin Reuptake Inhibitor Increases Pseudarthrosis Rates in Anterior Cervical Discectomy and Fusions [PDF]
Asian Spine Journal, 2023 Study Design Retrospective cohort. Purpose To determine (1) the effects of serotonin reuptake inhibitors in pseudarthrosis rates after anterior cervical decompression and fusion (ACDF) and (2) to identify patient-reported outcome measures in patients ...
Mark James Lambrechts +15 more
doaj +1 more source
Sertraline and Phenytoin Drug Interaction in a Geriatric Patient [PDF]
, 2017 This report presents the case of a 78-year-old man residing in a nursing home who presented with a 2-month history of increasing lethargy and confusion. These symptoms coincided with the initiation of sertraline in the patient.
Caprio, Thomas V. +4 more
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Preclinical discovery of duloxetine for the treatment of depression [PDF]
, 2012 Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María +4 more
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Selective serotonin reuptake inhibitors and Alzheimer’s disease
Neural Regeneration Research, 2020 Given the failure to develop disease-modifying therapies for Alzheimer’s disease (AD), strategies aiming at preventing or delaying the onset of the disease are being prioritized. While the debate regarding whether depression is an etiological risk factor
Bernadette Mdawar +2 more
doaj +1 more source
Fluoxetine reduces murine graft-versus-host disease by induction of T cell immunosuppression [PDF]
, 2013 Serotonin reuptake inhibitors (SRIs) are widely used drugs in the treatment of depression and anxiety disorders. Although SRIs are generally regarded as safe drugs with relatively few side effects, literature suggests that high concentrations of SRIs may
Billiau, An D +6 more
core +3 more sources
A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. [PDF]
, 2020 Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and
Aitchison, Katherine J +14 more
core +2 more sources
Dosing of Selective Serotonin Reuptake Inhibitors [PDF]
The Primary Care Companion For CNS Disorders, 2001 Sir: I am writing to address an inaccuracy written about the dosing and administration of selective serotonin reuptake inhibitor (SSRI) medications in the article by Marken and Munro published in the December 2000 issue of the Companion.1 Contrary to the contention by Drs. Marken and Munro that sertraline is more effective at the high end of the dosage
openaire +2 more sources
Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]
, 2015 Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian +3 more
core +4 more sources
Chirality of Modern Antidepressants: An Overview [PDF]
Advanced Pharmaceutical Bulletin, 2017 The majority of modern antidepressants (selective serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors) have one or two centers of asymmetry in their structure; resulting in the formation of enantiomers which may ...
Monica Budău +4 more
doaj +1 more source