Selective Sweeps Under Dominance and Inbreeding [PDF]
G3: Genes, Genomes, Genetics, 2020 A major research goal in evolutionary genetics is to uncover loci experiencing positive selection. One approach involves finding ‘selective sweeps’ patterns, which can either be ‘hard sweeps’ formed by de novo mutation, or ‘soft sweeps’ arising from ...
Matthew Hartfield, Thomas Bataillon
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Candidate selective sweeps in US wheat populations [PDF]
The Plant GenomeExploration of novel alleles from ex situ collection is still limited in modern plant breeding as these alleles exist in genetic backgrounds of landraces that are not adapted to modern production environments.
Sajal R. Sthapit +5 more
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Recent Selective Sweeps in North American Drosophila melanogaster Show Signatures of Soft Sweeps [PDF]
PLoS Genetics, 2015 Adaptation from standing genetic variation or recurrent de novo mutation in large populations should commonly generate soft rather than hard selective sweeps.
Nandita R Garud +2 more
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Localization of adaptive variants in human genomes using averaged one-dependence estimation [PDF]
Nature Communications, 2018 Selective sweeps are events in which beneficial mutations spread rapidly through a population. Here, Sugden et al. develop SWIF(r), a probabilistic classification framework for detecting and localizing selective sweeps, and apply it to genomic data from ...
Lauren Alpert Sugden +5 more
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Sweepstakes reproductive success via pervasive and recurrent selective sweeps [PDF]
eLife, 2023 Highly fecund natural populations characterized by high early mortality abound, yet our knowledge about their recruitment dynamics is somewhat rudimentary.
Einar Árnason +3 more
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Soft selective sweeps: Addressing new definitions, evaluating competing models, and interpreting empirical outliers [PDF]
PLoS Genetics, 2022 The ability to accurately identify and quantify genetic signatures associated with soft selective sweeps based on patterns of nucleotide variation has remained controversial. We here provide counter viewpoints to recent publications in PLOS Genetics that
Parul Johri +2 more
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Selective sweeps on different pigmentation genes mediate convergent evolution of island melanism in two incipient bird species. [PDF]
PLoS Genetics, 2022 Insular organisms often evolve predictable phenotypes, like flightlessness, extreme body sizes, or increased melanin deposition. The evolutionary forces and molecular targets mediating these patterns remain mostly unknown.
Leonardo Campagna +3 more
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S/HIC: Robust Identification of Soft and Hard Sweeps Using Machine Learning
PLoS Genetics, 2016 Detecting the targets of adaptive natural selection from whole genome sequencing data is a central problem for population genetics. However, to date most methods have shown sub-optimal performance under realistic demographic scenarios. Moreover, over the
Daniel R Schrider
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Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation. [PDF]
PLoS Computational Biology, 2013 Selective sweeps are at the core of adaptive evolution. We study how the shape of coalescent trees is affected by recent selective sweeps. To do so we define a coarse-grained measure of tree topology. This measure has appealing analytical properties, its
Haipeng Li, Thomas Wiehe
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eLife, 2022 Analyses of genetic variation in many taxa have established that neutral genetic diversity is shaped by natural selection at linked sites. Whether the mode of selection is primarily the fixation of strongly beneficial alleles (selective sweeps) or ...
David A Murphy +3 more
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