Results 61 to 70 of about 1,228,536 (301)
Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors. [PDF]
, 2011 Matrix metalloproteinases are zinc-containing enzymes capable of degrading all components of the extracellular matrix. Owing to their role in human disease, matrix metalloproteinase have been the subject of extensive study.
de Oliveira, César AF +2 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Zinc binding groups for histone deacetylase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency of HDACIs.
Lei Zhang +4 more
doaj +1 more source
Intradural Spinal Cord Stimulation: Performance Modeling of a New Modality
Frontiers in Neuroscience, 2019 Introduction: Intradural spinal cord stimulation (SCS) may offer significant therapeutic benefits for those with intractable axial and extremity pain, visceral pain, spasticity, autonomic dysfunction and related disorders.
David J. Anderson +9 more
doaj +1 more source
Optimization of parameters affecting separation of gas mixture of O2, N2, CO2 and CH4 by PMP membrane modified with TiO2, ZnO and Al2O3 nanoparticles [PDF]
Polyolefins Journal, 2019 The application of membranes in various industries is one of the most urgent needs to reduce energy consumption and environmental pollutants as well as low investment costs in the process of separation.
Afshar Alihosseini +2 more
doaj +1 more source
Generation of Direction Selectivity by Isotropic Intracortical Connections [PDF]
, 1992 To what extent do the mechanisms generating different receptive field properties of neurons depend on each other? We investigated this question theoretically within the context of orientation and direction tuning of simple cells in the mammalian visual ...
Koch, Christof +2 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Selective Detection of NO and NO2 with CNTs-Based Ionization Sensor Array
Micromachines, 2018 The accurate detection of NOx is an important issue, because nitrogen oxides are not only environmental pollutants, but also harm to human health. An array composed of two carbon nanotubes (CNTs)-based ionization sensors with different separations is ...
Hui Song, Kun Li, Chang Wang
doaj +1 more source
Application of Modified Clay Catalysts in Oligomerization of Light Olefins [PDF]
Journal of Pure and Applied Chemistry Research, 2018 The oligomerization of light olefins to high-octane clean engine fuels is one possible way to solve increased requirements for motor fuels. This paper presents a study of catalytic oligomerization of C2-C4 olefins on Ru-Fe supported pillared clay ...
Raila Toktassyn, B.T. Utelbayev
doaj +1 more source
Monte Carlo study of gating and selection in potassium channels
, 2011 The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles.
A. L. Hodgkin +6 more
core +1 more source