Results 111 to 120 of about 97,028 (300)

Oxidative stress in the pathogenesis of systemic scleroderma: An overview [PDF]

, 2018
Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability
Gambardella, Lucrezia, Giovannetti, Antonello, Malorni, Walter, Pietraforte, Donatella, Straface, Elisabetta, Vona, Rosa   +5 more
core   +1 more source

A leaf phenomics approach for estimating belowground traits in North American licorice

American Journal of Botany, EarlyView.
Abstract Premise Selective breeding over thousands of years has prioritized aboveground yield, with little regard for changes belowground. Roots underpin plant growth and resilience, but our knowledge of these critical structures lags behind that of aboveground structures.
Zachary N. Harris, Vivian Tran, Emelyn Piotter, Meredith T. Hanlon, Matthew J. Rubin, Allison J. Miller   +5 more
wiley   +1 more source

Selenium’s Role in Plant Secondary Metabolism: Regulation and Mechanistic Insights

Agronomy
Selenium (Se) is an indispensable trace element for humans and other animals. Various studies have demonstrated the beneficial effects of Se on plants, including the promotion of growth, accumulation of secondary metabolites, and enhancement of ...
Yan Zhou, Kaiqin Nie, Lulu Geng, Yixin Wang, Linling Li, Hua Cheng   +5 more
doaj   +1 more source

Selenium metabolism heterogeneity in pan-cancer: insights from bulk and single-cell RNA sequencing. [PDF]

J Cancer Res Clin Oncol, 2023
Fu X, Deng Y, Xu H, Shu Y, Chen HN.
europepmc   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Gut microbiota: a new perspective for bioavailability of selenium and human health

npj Science of Food
The gut microbiota can metabolise and transform selenium, and even compete with the host for it. This provides new insights into the bioavailability of selenium and the mechanisms through which it exerts its beneficial effects.
Xuehua Wang, Yan Zhong, Zhenzhou Zhu, Na Zhang, Xu Chen, Feifei Wang, Li Wang, Cheng Chen, Jiangling He, Shuyi Li   +9 more
doaj   +1 more source

Multi‐omics data mining combined with experimental validation reveals ferroptosis‐ and autophagy‐associated hub genes as diagnostic candidates and immune modulators in atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
Using the GSE225650 dataset, we performed differential expression gene (DEG) screening, Weighted Gene Coexpression Network Analysis (WGCNA), and immune infiltration profiling on atherosclerosis (AS) samples, yielding 104 shared candidate genes. Subsequently, these 104 candidate genes were intersected with ferroptosis‑ and autophagy‑related gene sets ...
Xinou Zheng, Jinling Zheng, Xuezhuang Li, Hua Chen, Li Zhang, Yuqiong Zhao, Yahao Ling   +6 more
wiley   +1 more source

Selenium Metabolism and Selenoproteins in Prokaryotes: A Bioinformatics Perspective. [PDF]

Biomolecules, 2022
Zhang Y, Jin J, Huang B, Ying H, He J, Jiang L.   +5 more
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source