Results 211 to 220 of about 27,808 (261)

Delivery of selenium to selenophosphate synthetase for selenoprotein biosynthesis.

Biochimica et Biophysica Acta - General Subjects, 2018
BACKGROUND Selenophosphate, the key selenium donor for the synthesis of selenoprotein and selenium-modified tRNA, is produced by selenophosphate synthetase (SPS) from ATP, selenide, and H2O.
Ryuta Tobe, H. Mihara
semanticscholar   +1 more source

Selenoprotein synthesis and regulation in Archaea.

Biochimica et Biophysica Acta - General Subjects, 2018
BACKGROUND The major biological form of selenium is that of the co-translationally inserted amino acid selenocysteine (Sec). In Archaea, the majority of proteins containing Sec, selenoproteins, are involved in methanogenesis.
M. Rother, Vivien Quitzke
semanticscholar   +1 more source

Molecular Biology of Selenoproteins

Annual Review of Nutrition, 1990
Article de synthese sur la biologie moleculaire des selenoproteines. Etude du metabolisme du selenium (Se), des quatre classes de selenoproteines, de la glutathion peroxidase (GPX) Se-dependante et non dependante, de la phospholipide hydroperoxide GPX, de la GPX plasmatique, de seleno-proteines de mammiferes (rats).
openaire   +2 more sources

Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions.

Free Radical Biology & Medicine, 2018
In its 200 years of history, selenium has been defined first as a toxic element and finally as a micronutrient. Selenium is incorporated into selenoproteins as selenocysteine (Sec), the 21st proteinogenic amino acid codified by a stop codon.
Noelia Fradejas-Villar
semanticscholar   +1 more source

Selenoproteins and Cancer Prevention

Annual Review of Nutrition, 2012
The discovery of multiple selenoproteins has raised tantalizing questions about their role in maintaining normal cellular function. Unfortunately, many of these remain inadequately investigated. While they have a role in maintaining redox balance, other functions are becoming increasingly recognized.
Cindy D, Davis, Petra A, Tsuji, John A, Milner   +2 more
openaire   +2 more sources

Natural and synthetic selenoproteins

Current Opinion in Chemical Biology, 2014
Once considered highly toxic, the element selenium is now recognized as a micronutrient essential for human health. It is inserted co-translationally into many proteins as the non-canonical amino acid selenocysteine, providing the resulting selenoprotein molecules with a range of valuable redox properties; selenocysteine is also increasingly exploited ...
Norman, Metanis, Donald, Hilvert
openaire   +2 more sources

Selenocysteine and selenoproteins

2004
Selenium occurs normally in living things as a highly specific component of certain enzymes and amino acid transfer nucleic acids (tRNAs). In bacteria, biosynthesis of essential selenoenzymes has been shown to be unaffected by wide variations in sulfur levels.
openaire   +1 more source

Selenoproteins in bladder cancer

Clinica Chimica Acta, 2012
Selenoproteins with genetically encoded selenium (Se) are very important in response to oxidative stress, redox balance and regulation of various metabolic and developmental processes. Although increased circulating Se has been associated with 33% risk reduction of bladder cancer, there are little data on selenoprotein expression at the protein and ...
openaire   +2 more sources

Mammalian selenoproteins.

Journal of trace elements and electrolytes in health and disease, 1993
Selenium (Se) is an essential trace element for animals and humans. Its biological role was established following the discovery that Se is a structural component of the active center of the enzyme glutathione peroxidase (GSH-Px). During the last decade remarkable progress has been made in the recognition of the structure and function of several ...
openaire   +1 more source

Selenoprotein P

2002
Gavin E, Arteel, Lars-Oliver, Klotz, Darius P, Buchczyk, Helmut, Sies   +3 more
openaire   +2 more sources